Objective:To study the efficacy of maintenance therapy in patients with reflux esophagitis caused by radical proximal gastrectomy. Methods: We reviewed clinical data from 48 patients with esophagitis who had undergone radical proximal gastrectomy for gastric cancer in Henan Tumor Hospital from Mar 2009 to Mar 2010. The efficacy of pantoprazole and Dali-tong granules were evaluated. All patients completed a quality-of-life questionnaire [quality of life questionnaire of stomach 22 (QLQ-STO22)] post-operatively at 3 months, 6 months and yearly thereafter. Results: Both pantoprazole and Dalitong granules were effective, however, the combination therapy showed more obviously advantages in some terms of QLQ-STO22. Conclusions: The combination therapies of pantoprazole and Dalitong granules have the best treatment effect for patients with reflux esophagitis after radical proximal gastrectomy.%目的:总结泮托拉唑肠溶片联合达立通颗粒对根治性近端胃切除术后反流性食管炎的维持治疗效果.方法:回顾分析河南省肿瘤医院普外科2009年3月-2010年3月48例因根治性近端胃切除术后经胃镜确诊为反流性食管炎患者的临床资料,评价泮托拉唑肠溶片、达立通颗粒单独用药和联合用药的疗效.并对患者术后3个月、6个月、1年进行生活质量调查问卷(quality of life questionnaire of stomach 22,QLQ-STO22)评分.结果:单独应用泮托拉唑肠溶片或达立通颗粒即可明显改善患者病情,但联合用药在改善患者生活质量方面更具优势.结论:联合应用泮托拉唑肠溶片和达立通颗粒有助于提高根治性近端胃切除术后反流性食管炎的疗效.
展开▼
