TNFAIP8家族基因单核苷酸多态性位点在宫颈癌预后评估中的作用

摘要

Objective:To investigate the predictive value of polymorphisms in the tumor necrosis factor‐α‐induced protein 8 (TNFalP8) gene family in the prognosis of cervical cancer .Methods:A total of 144 cervical cancer patients who had been followed up for at least two years were recruited . Three polymorphism sites TNFalP8‐rs11064 , TNFalP8‐rs3813308 and TNFalP8L1‐rs1060555 in the TNFalP8 gene family were genotyped by the Taqman assay .The associations of polymorphisms in the TNFalP8 gene family with prognosis of cervical cancer were analyzed . Results:Compared with CG/CC genotypes ,tumor recurrence in TNFalP8L1‐rs1060555 GG genotype carriers increased (adjusted HR=3 .25 ,95% CI:1 .06‐9 .95) .Combined analysis for the three polymorphisms indicated that compared with 0‐1 risk genotype carriers ,tumor recurrence in 2‐3 risk genotype carriers increased (adjusted HR = 2 .55 ,95% CI:1 .02‐6 .36) . Conclusions:Polymorphisms in TNFalP8 gene family may be predictive biomarkers for prognosis of cervical cancer .%目的：探讨肿瘤坏死因子α诱导蛋白8（tumor necrosis factor‐α‐induced protein 8，TNFAIP8）家族基因的单核苷酸多态性（single nucleotide polymorphism ，SNP）位点在宫颈癌预后评估中的作用。方法：选择2008—2009年行根治性子宫切除术并获得至少2年随访的144例宫颈癌患者。采用 Taqman探针检测患者 TNFAIP8家族基因中3个多态性位点（TNFAIP8‐rs11064、TNFAIP8‐rs3813308和TNFAIP8L1‐rs1060555）的基因分型。分析 TNFAIP8家族基因SNP位点与宫颈癌预后的关系。结果：携带TNFAIP8L1‐rs1060555 GG的宫颈癌患者相较于携带CG／CC基因型者，肿瘤复发的危险度显著增加（校正HR＝3．25，95％ CI：1．06～9．95）。联合效应分析发现，携带TNFAIP8基因家族2～3个危险基因型的患者相较于携带0～1个危险基因型者，肿瘤复发的危险度显著增加（校正 HR＝2．55，95％ CI：1．02～6．36）。结论：TNFAIP8家族基因的SNP位点有望为宫颈癌的预后评估提供参考。