慢性肾脏病早期患者高敏心肌肌钙蛋白T水平及其影响因素分析

摘要

Objective:To study the influencing factors of serum high-sensitivity cardiac troponin T(hs-cTnT)levels in chronic kidney disease(CKD)patients.Methods:The clinical data of CKD patients treated at a hospital were collected.Fasting blood samples were collected to measure the level of hs-cTnT.Single factor analysis,univariate linear regression analysis and multiple linear regression analysis were carried out to screen the influencing factors of hs-cTnT.Objective:The level of hs-cTnT was detected in 324 CKD patients,and the median level was 0.012 μg/L.In early-stage CKD patients,Cys C,UACR and left ventricular mass index(LVMI)were positively correlated with hs-cTnT level(P<0.05),and the hs-cTnT level increased significantly in CKD patients with hypertension or diabetes.The estimated glomerular filtration rate(eGFR)was negatively correlated with the hs-cTnT level(P=0.003).Conclusions:The elevated levels of hs-cTnT in CKD patients are associated with a variety of factors,so clinicians should make a comprehensive assessment of the causes of elevated hs-cTnT level.%目的:探讨慢性肾脏病(CKD)早期患者体内高敏心肌肌钙蛋白T(hs-cTnT)水平的影响因素.方法:选取于某院治疗的CKD早期患者.采集患者的空腹血,检测hs-cTnT的水平.用单因素分析、单因素线性回归分析以及多因素回归分析逐步筛选影响hs-cTnT的主要因素.结果:共324例患者hs-cTnT含量升高(中位数0.012 μg/L).CKD早期患者中,年龄、胱抑素C水平、尿白蛋白/肌酐比(UACR)及左室质量指数(LVMI)与hs-cTnT水平正相关(P<0.05);合并高血压、糖尿病者体内hs-cTnT水平明显上升(P<0.05);评估肾小球滤过率(eGFR)与hs-cTnT水平负相关(P=0.003).结论:CKD患者体内hs-cTnT水平升高与多种因素相关,临床医师应对hs-cTnT水平升高的原因进行综合评估.