骨科植入物表面抗感染修饰及其骨整合性的研究进展

摘要

植入物相关感染和无菌性松动是导致内固定或关节假体失效的最主要原因,已然成为了骨科医师亟待解决的难题.一个理想的骨科植入物需要同时具备良好的抗菌性与骨整合特性,从而取得长期稳定的内固定效果.本文从该点出发,综合了国内外在植入物表面抗感染修饰研究领域的最新进展,着重总结与阐述了目前植入物表面抗感染修饰的最新策略,同时对促进植入物表面骨整合的相关策略进行了综述,为今后的研究提供了新的思路.%The two leading causes of failure for joint arthroplasty prostheses or internal fixation are implant-associated infection and aseptic loosening, which have been great challenges for orthopaedic surgeons. Since strong osseointegration and prevention of infection are both required to achieve long-term success of the implant,in this review we discuss recent progress in surface modification of orthopaedic implants that can inhibit microbial cells,as well as related strategies of promoting osseointegration,and provide innovation for future researches.