成分输血对慢性贫血患者临床症状及血红蛋白和红细胞水平的影响

摘要

目的 探讨成分输血对慢性贫血患者临床症状以及血红蛋白、红细胞水平的改善作用.方法 以随机数字法将80例慢性贫血患者分为2组,每组40例.对照组给予全血治疗,观察组给予成分输血治疗.治疗前后,检测患者血液学相关指标[红细胞(RBC)平均值、血红蛋白(Hb)平均值和血细胞比容(HCT)].并统计输血情况相关指标[平均输血量和每次输血间隔时间]、治疗效果和不良反应.结果 治疗后,观察组平均输血量为(589.73±48.54)mL明显低于对照组的(986.48±65.43)mL(P<0.05);观察组每次输血间隔时间为(38.64±5.83)d明显高于对照组的(30.39±4.35)d (P<0.05).治疗后,两组RBC、Hb、及HCT水平均明显升高(P<0.05),且观察组RBC、Hb、及HCT水平分别为(3.58±0.32)×1012/L、(81.82±4.92)g/L、(0.42±0.08)L/L明显高于对照组的(3.03±0.36)×1012/L、(73.27±4.52)g/L、(0.35±0.04) L/L,均差异有统计学意义(P<0.05).观察组治疗总有效率为90.0%,显著高于对照组77.5% (P<0.05).观察组不良反应总发生率为10.0%,显著低于对照组35.0% (P>0.05).结论 成分输血比全血治疗更能显著改善慢性贫血患者的血红蛋白、红细胞水平和临床症状,不良反应更少.%Objective To explore the improvement effects of blood component transfusion on clinical symptoms,hemoglobin and red blood cell of patients with chronic anemia.Methods 80 patients with chronic anemia were randomly divided into two groups,40 cases in each group.Patients of control group were given whole blood treatment,and patients of observation group were given component transfusion therapy.Hematological indicators[mean red blood cell (RBC),mean hemoglobin (Hb) and hematocrit (HCT)] were detected before and after treatment.Blood transfusion indicators[blood transfusion amount and transfusion interval,therapeutic effect and adverse reactions of two groups were accounted.Results The blood transfusion amount of observation group [(589.73±48.54) mL] was significantly lower than that of the control group [(986.48±65.43) mL] (P<0.05);and the transfusion interval of observation group [(38.64±5.83)d] was significantly higher than the control group [(30.39±4.35)d](P<0.05).After treatment,the RBC,Hb,and HCT of two groups were increased obviously (P<0.05),and RBC,Hb,and HCT in observation group [(3.58±0.32)×1012/L,(81.82±4.92)g/L,(0.42±0.08)L/L] increased more obviously,and the differences between the twogroups were statistically significant(P<0.05).The total effective rate of observation group (90.0%) was significantly higher than control group(77.5%,P<0.05).The adverse reactions rate of observation group (10.0%) was significantly lower than control group(35.0%,P>0.05).Conclusion Blood component transfusion therapy could significantly improve the clinical symptoms,hemoglobin and red blood cell of patients with chronic anemia,and fewer adverse events.