[目的]探讨纳米炭标记在家族性腺瘤性息肉病非手术治疗中的应用价值.[方法]纳入根据家族史并经结肠镜和组织病理学检查确诊为家族性腺瘤性息肉病的28例患者.首次接诊后在距肛缘15 cm处行内镜下行黏膜下纳米炭标记,定期行肠镜检查治疗,同时记录纳米炭标记的操作时间、维持时间、治疗前后距离肛门口15 cm处的息肉数目变化.[结果]纳米炭标记操作时间为(3.83±0.34)min.标记持续时间达6个月的有25例(89.29％);达12个月的有23例(82.14％).治疗前后息肉数分别为(28.75±14.93)个、(13.11±8.73)个,差异有统计学意义(P＜0.05).随访期间未发现标记引起的并发症.[结论]纳米炭标记可以明确家族性腺瘤性息肉病患者特定区域肠道的息肉数目的变化,评估治疗的疗效更加客观、有效,且应用安全度高,便于实施.%[Objective]To explore the application of charcoal nanoparticles tattooing in the non-operative treatment for patients with familial adenomatous polyposis. [Methods] Twenty-eight patients were diagnosed as familial adenomatous polyposis by colonoscopy, histopathological examinations and family history from April 2014 to June 2016 in Fuzhou General Hospital were involved in the study. In all the patients, 0.5 ml(5 mg)of charcoal nanoparticle was injected submucosally 15 cm away from the anal margin in the first reception, and the patients took regular therapy. Operation time, duration of charcoal nanoparticles, and the number of polyps in specific intestine segment was calculated meanwhile during regular colonoscopy. [Results] The operation time of charcoal nanoparticles tattooing was (3.83 ± 0.34) min, 25 cases (89.29％)was tattooed more than 6 months while 23(82.14％)cases more than 12 months. The number of polyps before and after the treatment was(28.75 + 14.93)and(13.11 ±8.73) respectively(P＜0.05). No complication was found during follow-up. [Conclusion]The charcoal nanoparticles tattooing can be used to evaluate the non-operative treatment in calculating the number of colonic polyps of specific intestinal segment in patients with familial adenomatous polyposis. It is also objective and convenient to perform.
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