老年高血压病患者血vWF、GMP－ 140、CRP含量的研究

摘要

目的：研究老年高血压病(EH)患者的血管内皮细胞损伤、血小板活化和炎症因子改变。方法：选择31例Ⅰ、Ⅱ期EH患者和28例老年正常对照者，测定其血浆vWF因子、α颗粒膜蛋白－140(GMP－140)和血清C反应蛋白(CRP)含量。结果：EH组患者血浆vWF、GMP－140含量明显高于对照组；EH组血浆vWF含量与收缩压呈正相关。结论：Ⅰ、Ⅱ期老年EH患者有明显的内皮细胞损伤和血小板活化，血管内皮细胞损伤与收缩压呈正相关。%Objective: To investigate the changes of endothelial dysfunction, platelet activation and inflammation factor in elderly hypertensive (EH) patients. Methods: Thirty-one patients with EH in stage I－Ⅱ and 28 elderly healthy controls were selected as subjects, their plasma concentrations of vWF, GMP－140 and serum concentrations of CRP were examined. Results: Plasma vWF and GMP－140 levels were higher in EH patients than its of control group. Level of vWF was positive correlated with systolic pressure. Conclusion: This study suggests that stage Ⅰ－Ⅱ of EH patients have significant endothelial dysfunction and platelet activation. Endothelial dysfunction is positive correlated with systolic pressure.