Objective: To study effects of angiotensin II receptor blocker valsartan on plasma levels of nitric oxide (NO), endothelin (ET) and inflammatory factors in patients with essential hypertension (EH) complicated impaired glucose tolerance (IGT). Methods: A total of 42 EH + IGT patients were given valsartan 80 mg oral, once a day, and another 40 healthy adults were regard as normal control group. Detections were performed on blood glucose, 2h postprandial blood glucose (2hPG) , homeostasis model-insulin resistance index (HOMA- IR) , levels of NO and serum inflammatory factors in the two groups before and after treatment. Results: Compared with normal control group, levels of blood pressure, 2hPG, HOMA-IR, tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and ET significantly increased, and NO level significantly decreased in EH + IGT group (P<0. 01) s compared with before treatment, there were significant decrease in levels of blood pressure [(163. 95±8. 0) / (99.10±ll. 8) mm-Hg vs. (132. 93±10. 7) / (82.14±9. 5) mmHg], 2hPG [(9.10±l. 10) mmol/L vs. (7. 85±1.15) mmol/L], HO-MA-IR[(3. 90±2.11) vs. (2.73 ±1.71)], plasma ET [ (47. 84 ±7.79) ng/L vs. (31.84 ±4.5) ng/L], TNF-a[ (32.30 ±5.49) ng/L vs. (26. 83±4.83) ng/L] and IL-6 [(112.70 ±24.79) ng/L vs. (77. 22±11. 53) ng/L] and significant increase in plasma level of NO [ (38.1±7. 36) f*mol/L vs. (43. 38±7. 52) nmol/L] in EH + IGT group after eight-week treatment with valsartan, P展开▼
