有氧运动对冠心病患者内皮功能的影响

摘要

Objective:To explore the effects of aerobic exercise on endothelial function in patients with coronary heart disease (CHD). Methods: A total of 60 CHD patients lacked of exercises were randomly and equally divided into exercise intervention group (performed aerobic exercise, 30 min 5 times/week) and medicinal treatment group (received medicinal treatment with metoprolol and nitroglycerol) . Both groups were treated for 12 weeks. Enzyme linked im-munosorbent assay was used to measure serum levels of intercellular adhesion molecule—1 (ICAM—1) and interleukin —18 (IL—18). and level of nitric oxide (NO) was measured by enzyme method. Another 20 healthy subjects were selected as normal control group. Results: Compared with normal controls, serum levels of ICAM—1 [(246. 43±39. 32) ng/ml vs. (335. 03±61. 99) ng/ml] and IL-18 [ (230. 60±29. 15) pg/ml vs. (308. 67±48. 08) pg/ml] significantly increased, level of NO [ (80. 34± 13. 22) ^mol/L vs. (48. 54±7. 64) μmol/L] significantly decreased in CHD patients, P<0. 01 all. Compared with before treatment, after 12 — week exercise intervention, levels of ICAM—1 [ (333. 47±57. 29) ng/ml vs. (304. 66±45. 58) ng/ml] and IL-18 [ (310. 82±47. 37) pg/ml vs. (290. 18±38. 47) pg/ml] significantly decreased, and level of NO [(49. 88±7. 90)μmol/L vs. (54. 00±8. 83) μmol/L] significantly increased in exercise intervention group, P<0. 05 all. Effect of exercise intervention was equal with that of medicinal treatment (P>0. 05). Conclusion; Long—term regular aerobic exercise can significantly improve endothelial function of patients with coronary heart disease.%目的:观察有氧运动对冠心病患者内皮功能的影响.方法:入选60例平时缺乏运动的冠心病患者,随机均分为运动干预组和药物治疗组,运动干预组进行有氧运动,每周5次,每次30min.药物治疗组给予美托洛尔、硝酸甘油等药物治疗.各组干预12周,干预前后采用酶联免疫吸附试验法测定血清细胞间粘附分子-1(ICAM-1)和白介素-18(IL-18)水平,酶法测定一氧化氮(NO)水平.另选20例健康体检者作为正常对照组.结果:与健康人比较,冠心病患者血清ICAM-1[(246.43±39.32)ng/ml比(335.03±61.99)ng/ml]和IL-18[(230.60±29.15)pg/ml比(308.67±48.08)pg/ml]水平明显升高,NO[(80.34±13.22)μmol/L比(48.54±7.64)μpmol/L]水平明显降低(P均<0.01).与治疗前比较,经12周运动干预后,ICAM-1[(333.47±57.29)ng/ml比(304.66±45.58)ng/ml]和IL-18[(310.82±47.37)pg/ml比(290.18±38.47)pg/ml]水平明显下降,NO[(49.88±7.90)μmol/L比(54.00±8.83)μmol/L]水平明显升高(P<0.05).运动干预与药物治疗效果相当(P>0.05).结论:长期规律有氧运动能够显著改善冠心病患者的内皮功能.