不同剂量阿托伐他汀钙预防颈动脉粥样硬化患者脑梗塞的作用

摘要

Objective: To investigate preventive effects of different doses of atorvastatin calcium on cerebral infarction in patients with carotid atherosclerosis. Methods:A total of 140 cases with carotid atherosclerosis were randomly divided into two groups: low dose group (was given atorvastatin calcium l0mgight), high dose group (received atorvastatin calcium 20mgight) , and incidence rates of cerebral infarction of the two groups were observed and analyzed. Results-. Incidence rate of cerebral infarction in high dose group was significantly lower than that of low dose group (1. 43％ vs. 8. 57％ . P＜0. 05) , but there was no significant difference between the two groups in incidence rate of liver dysfunction within one year (P＞0. 05). Conclusion: Atorvastatin calcium can regulate blood lipid, stabilize atherosclerotic plaque and improve vascular endothelial function. The dose of 20mgight of atorvastatin calcium could decrease incidence rate of cerebral infarction and no significantly increase its side effects compared with dose of 10mg/ night.%目的:探讨不同剂量阿托伐他汀钙片预防颈动脉粥样硬化患者脑梗塞的作用.方法:140例颈动脉粥样硬化患者被随机分为两组:低剂量他汀组(给予阿托伐他汀钙片10mg/晚),高剂量他汀组(给予阿托伐他汀钙片20mg/晚),观察两组脑梗塞的发生率.结果:高剂量他汀组脑梗塞发生率明显低于低剂量他汀组(1.43%∶8.57%,P<0.05),1年内两组肝功能异常发生率无显著差异(P>0.05).结论:阿托伐他汀钙片具有调控血脂,稳定动脉粥样斑块,改善血管内皮功能状态的作用,20mg/晚剂量较10mg/晚剂量有更低的脑梗塞发生率,且副作用无明显增加.