阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛的疗效

摘要

目的：研究阿托伐他汀（ATO）联合曲美他嗪（TRZ）对不稳定型心绞痛（UAP）的疗效。方法：选择2011年3月到2013年3月在我院被确诊为UAP的患者100例。以数字法随机分为 ATO组（常规药物治疗基础上加入 ATO，50例），ATO＋ TRZ组（在ATO组基础上另加用TRZ，50例）。对比两组疗效及治疗前后血脂水平情况。结果：ATO＋TRZ组，总有效率为96.00％（48/50），显著高于 ATO组的76.00％（38/50）（P＜0.05）。治疗后两组血脂水平均有显著改善，与 ATO 组比较，ATO＋TRZ 组总胆固醇[TC，（4.78±0.65）mmol/L 比（4.12±0.60）mmol/L]、甘油三酯[TG，（1.54±0.51）mmol/L比（1.02±0.53）mmol/L]及低密度脂蛋白-胆固醇[LDL-C，（3.02±0.46）mmol/L比（2.32±0.45）mmol/L]水平显著降低，高密度脂蛋白胆固醇[HDL-C，（1.57±0.58）mmol/L比（2.12±0.55）mmol/L]显著升高，差异均有统计学意义（P 均＜0.05）。结论：阿托伐他汀与曲美他嗪联合治疗不稳定型心绞痛患者，疗效更显著，值得临床推荐。%Objective:To study the therapeutic effect of atorvastatin (ATO)combined trimetazidine (TRZ)on un-stable angina pectoris (UPA).Methods:A total of 100 UAP patients in our hospital from Mar 2011 to Mar 2013 were enrolled.According to number table method,they were randomly divided into ATO group (received ATO ad-ditionally based on routine medication,n=50)and ATO+TRZ group (received TRZ additionally based on ATO group treatment,n=50).Levels of blood lipids and therapeutic effects were compared between two groups before and after treatment.Results:Total effective rate was 96.00% (48/50)in ATO+TRZ group,which was signifi-cantly higher than that of ATO group (76.00%),P<0.05.Compared with ATO group,there were significant re-ductions in levels of total cholesterol [TC,(4.78±0.65)mmol/L vs.(4.12±0.60)mmol/L],triglyceride [TG, (1.54±0.51)mmol/L vs.(1.02±0.53)mmol/L]and low density lipoprotein cholesterol [LDL-C,(3.02±0.46) mmol/L vs.(2.32±0.45)mmol/L],and significant rise in level of high density lipoprotein cholesterol [HDL-C, (1.57±0.58)mmol/L vs.(2.12±0.55)mmol/L]in ATO+TRZ group,P<0.05 all.Conclusion:Atrovastatin combined trimetazidine can more significantly improve therapeutic effect in patients with unstable angina pectoris, which should be recommended in clinic.