目的:探讨急性 ST段抬高型心肌梗死(STEMI)患者行经皮冠状动脉介入治疗(PCI)对脑利钠肽(BNP)水平及心室重构的影响。方法:151例诊断为 STEMI的患者根据其治疗方式分为3组:A组(52例,行急诊 PCI治疗),B组(49例,择期行PCI治疗),C组(50例,予以标准药物治疗)。比较各组患者治疗前后 BNP水平及左心室重构情况。结果:三组患者治疗前BNP水平比较无统计学差异(F=0.01,P>0.05),治疗后各组 BNP水平均显著下降,其中 A组下降较B组、C组显著[(242.7±101.3)ng/L比(466.2±113.5)ng/L比(601.4±126.7)ng/L],差异有显著性(P均<0.01)。各组治疗前左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)比较差异均无显著性(P>0.05);治疗后,三组心室上述指标均显著升高(P<0.05),其中 A、B组LVFS升高均较C组更明显[(28.9±7.6)%比(27.5±7.3)%比(22.6±6.9)%],而 A 组 LVEF 较 B 组、C 组升高[(57.9±6.2)%比(53.1±6.5)%比(50.9±5.7)%],差异有显著性(P均<0.01)。结论:经皮冠脉介入治疗急性 ST段抬高型心肌梗死患者能有效改善心室重构,同时降低脑利钠肽水平,且急诊经皮冠脉介入治疗比择期介入治疗疗效更明显。%Objective:To explore influence of percutaneous coronary intervention (PCI)on brain natriuretic peptide (BNP)level and ventricular remodeling in patients With acute ST elevation myocardial infarction (STEMI).Meth-ods:According to their therapeutic methods,a total of 151 patients diagnosed as STEMI Were divided into group A (n=52,received emergency PCI treatment),group B (n=49,received selective PCI treatment)and group C (n=50,received standard medication).BNP level and left ventricular remodeling Were compared among three groups before treatment and after treatment.Results:There Was no significant difference in BNP level among three groups before treatment (F=0.01,P>0.05),BNP level significantly decreased among three groups after treatment,com-pared With group B and C,there Was significant decrease in BNP level [(466.2±113.5)ng/L vs.(601.4±126.7) ng/L vs.(242.7±101.3)ng/L]in group A (P<0.01 all).There Were no significant difference in left ventricular end-diastolic volume (LVEDV),left ventricular end-systolic volume (LVESV),left ventricular ejection fraction (LVEF)and left ventricular fractional shortening (LVFS)among three groups before treatment (P>0.05 all);af-ter treatment,there Were significant increase in above ventricular indexes in three groups (P<0.05 all),compared With group C,there Were significant increase in LVFS [(22.6±6.9)% vs.(28.9±7.6)% vs.(27.5±7.3)%]in group A and B,compared With group B and C,there Was significant increase in LVEF [(53.1±6.5)% vs.(50.9± 5.7)% vs.(57.9±6.2)%]in group A (P<0.01 all).Conclusion:PCI could effectively improve ventricular re-modeling and decrease BNP level in STEMI patients,and emergency PCI shoWs more significant therapeutic effects than selective PCI.
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