社区人群中性粒细胞／淋巴细胞比值与心血管病危险因素的关系

摘要

目的：研究社区35～64周岁居民中性粒细胞／淋巴细胞比值（N／L ）与心血管病传统危险因素的关系。方法：2011年4月至2012年2月在沈阳市城区1884名居民（男548例，女1336例）中进行了心血管病及其相关疾病的基线情况调查。根据是否具有心血管危险因素，入选者被分为健康对照组（675例）和危险因素组（1209例）；根据具有的危险因素数量，危险因素组被进一步分为1个危险因素组（491例）、2个危险因素组（263例）和≥3个危险因素组（455例）。所有对象留取清晨血样、尿样检测血常规、尿常规、血糖、血脂等，比较分析各组的N／L比值。结果：在只有高血压、糖尿病、血脂异常、肥胖中任一危险因素的患者中，高血压和糖尿病患者的N／L水平显著高于健康对照组[1.55（1.15，1.95），1.60（1.21，2.07）比1.45（1.09，1.91）]， P均＜0.05，其余危险因素亚组与健康对照组间均无显著差异（ P均＞0.05）。在危险因素亚组间，≥3个危险因素组的N／L水平显著高于2个危险因素组[1.57（1.16，2.04）比1.41（1.07，1.89）， P＜0.05]，其余各组间无显著差异（ P＞0.05）。结论：中性粒细胞／淋巴细胞比值与高血压和糖尿病显著有关，且≥3个危险因素组的N／L水平显著高于2个危险因素组，N／L比值有助于评估心血管疾病风险。%Objective:To study the relationship between neutrophil to lymphocyte ratio (N/L) and traditional cardio‐vascular risk factors among community 35~64‐year‐old residents .Methods :A total of 1884 residents (548 males and 1336 females) from urban Shenyang city received baseline condition questionnaire on cardiovascular diseases and re‐lated diseases from Apr 2011 to Feb 2012. According to presence of cardiovascular risk factors or not ,subjects were divided into healthy control group (n=675) and risk factor group (n=1209);according to number of risk factors , risk factor group was further divided into one risk factor group (n=491) ,two risk factors group (n=263) and ≥3 risk factors group (n=455) .Morning blood sample and urine sample were retained to measure blood and urine rou‐tine ,blood glucose and blood lipid profile etc in all subjects .N/L was compared and analyzed among all groups .Re‐sults:Among patients with only one of following risk factors [hypertension ,diabetes mellitus (DM) ,dyslipidemia and obesity] ,N/L levels of patients with hypertension or DM were significantly higher than that of healthy control group [1.55(1.15 ,1.95) ,1.60(1.21 ,2.07) vs .1.45(1.09 ,1.91)] , P<0.05 both ,and there were no significant difference between any other one risk factor group and healthy control group , P>0.05 all .Among risk factor sub‐groups ,N/L level of ≥3 risk factors group was significantly higher than that of two risk factors group [1.57(1.16 , 2.04) vs .1.41(1.07 ,1.89) ,P<0.05] ,and there was no significant difference between any other two groups (P>0.05) .Conclusion:N/L significantly related to hypertension or DM ,and N/L level of ≥3 risk factors group was sig‐nificantly higher than that of two risk factors group ,N/L is helpful to assess risk of cardiovascular diseases .