B淋巴细胞在心血管疾病中的作用

摘要

B淋巴细胞来源于骨髓多能干细胞,通过分泌抗体、提呈抗原,提供协同刺激信号及分泌细胞因子等方式在体液免疫应答过程中发挥重要功能.现有证据表明,B淋巴细胞的成熟,活化,以及分泌抗体等作用可以对心血管系统产生重要影响.本文综合近期的研究,对B淋巴细胞在冠心病、心力衰竭以及扩张型心肌病中的作用及其机制进行综述.%B lymphocytes derive from bone marrow pluripotent stem cells,they play an important role in the process of humoral immune response by secreting antibodies,presenting antigens,providing costimulating signals and secre- ting cytokines etc.Existing evidence demonstrates that maturation,activation and antibody secretion effects of B lymphocytes have important influence on cardiovascular system.The present article synthesize recent researches, made a review about effect and its mechanisms of B lymphocytes in coronary heart disease,heart failure and dilated cardiomyopathy.