脉搏波传导速度在健康体检中的应用价值及其危险因素分析

摘要

目的:探讨沈阳地区臂踝脉搏波传导速度(baPWV)在健康体检中的应用价值及其危险因素.方法:选择在沈阳军区总医院健康管理中心接受定期健康体检符合入选条件的人员1610例,测定其双侧baPWV及其他相关指标,使用Logistic回归分析评估baPWV与年龄、人体质量指数(BMI)、动脉血压及血生化指标的关系.结果:1610例受检者中,男性baPWV值明显高于女性[(1397.93±239.08) cm/s比(1361.03±244.72) cm/s, P=0.003].同时,无论男性还是女性,baPWV均随年龄增加而增长.与baPWV正常组(<1400cm/s)比较,baPWV升高组(≥1400cm/s)年龄[(45.57±8.95)岁比(57.07±10.50)岁]明显较大,BMI[(25.25±6.82) kg/m2比(26.14±3.44) kg/m2]、空腹血糖[FBG, (4.88±1.73) mmol/L比(5.43±2.02) mmol/L]、低密度脂蛋白-胆固醇[LDL-C, (2.67±0.82) mmol/L比(2.84±0.77) mmol/L]、总胆固醇[TC, (4.88±0.99) mmol/L比(5.13±0.98) mmol/L]、甘油三酯[TG, (1.73±1.65) mmol/L比(2.15±1.91) mmol/L]、收缩压[SBP, (116.72±12.04) mmHg比(136.87±16.21) mmHg]、舒张压[DBP, (76.99±9.01) mmHg比(86.34±10.84) mmHg]及脉压[PP, (39.72±8.32) mmHg比(50.53±14.17) mmHg]显著升高(P均<0.01).多变量Logistic回归显示,年龄、FBG、TG、SBP、DBP、PP水平是baPWV升高的独立危险因素(OR=1.549~5.943, P<0.05或<0.01).结论:沈阳地区健康体检人群的baPWV与心血管危险因素密切相关,在心血管疾病风险筛查中具有较好的应用价值.%Objective: To explore application value of brachial-ankle pulse wave velocity (baPWV) in physical examination in Shenyang district and its risk factors.Methods: A total of 1610 cases, who received regular physical examination in health management center of General Hospital of Shenyang Military Command and met enrollment standards, were selected.Bilateral baPWV and other indexes were measured in all subjects.Logistic regression analysis was used to assess relationship among age, body mass index (BMI), arterial blood pressure, blood biochemical indexes and baPWV.Results: Compared with women, there was significant rise in baPWV[(1361.03±244.72) cm/s vs.(1397.93±239.08) cm/s, P=0.003]in men.baPWV rose along with age increased despite male or female.Compared with normal baPWV group (<1400 cm/s), there were significant rise in age[(45.57±8.95) years vs.(57.07±10.50) years], BMI[(25.25±6.82) kg/m2 vs.(26.14±3.44) kg/m2], fasting blood glucose[FBG, (4.88±1.73) mmol/L vs.(5.43±2.02) mmol/L], low density lipoprotein cholesterol[LDL-C, (2.67±0.82) mmol/L vs.(2.84±0.77) mmol/L], total cholesterol[TC, (4.88±0.99) mmol/L vs.(5.13±0.98) mmol/L], triglyceride[TG, (1.73±1.65) mmol/L vs.(2.15±1.91) mmol/L], systolic blood pressure[SBP, (116.72±12.04) mmHg vs.(136.87±16.21) mmHg], diastolic blood pressure[DBP, (76.99±9.01) mmHg vs.(86.34±10.84) mmHg]and pulse pressure[PP, (39.72±8.32) mmHg vs.(50.53±14.17) mmHg]in elevated baPWV group (≥1400cm/s), P<0.01 all.Multivariable Logistic regression analysis indicated that age, FBG,TG, SBP, DBP and PP levels were independent risk factors for elevated baPWV (OR=1.549~5.943, P<0.05 or <0.01).Conclusion: In Shenyang district, baPWV is closely correlated with cardiovascular risk factors, and it possesses good application value in physical examination and early risk screening of cardiovascular diseases.