Flow cytometry and image analysis technique were used to quantltate the nuclei of various soft tissue tumors. A single representing section from soft tissue sarcoma was used for histologic grading. Histologlc and cytometric comparative analyses showed that all 21 benign tumors were diploid. Among 62 cases of soft tissue sarcoma, 45(73%) were aneuploid. There was a significant difference in the nuclear area between benign and malignant tumors (P0. 01), dlploid and aneuploid tumors (P0. 05). The two new techniques are valuable In cellular quantitative measurement for soft tissue tumors.
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