THE CLINICAL SIGNIFICANCE OF MULTIDRUG RESISTANCE GENE (mdr1) EXPRESSION IN ACUTE LEUKEMIA

摘要

Objective: To study the clinical significance of multidrug resistance gene expression in acute leukemia.Methods: The relationships between drug resistance of leukemia cells and prognosis, multidrug resistance gene (mdr1) were examined in 85 patients with acute leukemia and 20 normal controls by reverse transcriptase polymerase chain reaction (RT-PCR). Results: The mdr1 positive rate in untreated group was 44.7 %. The complete remission (CR) rate of mdr1 positive patients (23.9 %) was significantly lower than that of mdr1 negative patients(88.5 %) (P＜0.005). The mdr1 expression level in relapsedrefractory group was higher than that of CR group. A gradually increased mdr1 mRNA level in CR patients indicated early relapse. Conclusion: The mdr1 positive rate in normal control and long-term survival patients was very low. The mdr1 expression was correlated with French-American-British Cooperative Group (FAB)classification. The mdr1 expression level was correlated with chemotherapeutic effect and prognosis. It is an unfavorable prognostic factor for patients with acute leukemia.