瑞舒伐他汀与双抗血小板联合治疗对脑梗死患者血清CRP、脑血管事件复发率及颈动脉斑块影响研究

摘要

Objective To investigate effect of combination of rosuvastatin and dual antiplatelet therapy on the serum CRP, cerebral vascular event recurrence rate and carotid artery plaque in cerebral infarction patients.Method 60 cerebral infarction patients were seleted and divided into the control group and the experiment group by different treatment(n=30).Two groups were treated by corresponding drugs.The serum levels of IMT, CRP, plaque area, plaque number and the cases of recurrent cerebral vascular events after 6 month were compared after treatment a month.Results Compared with the control group after treatment,the serum CRP were lower(P<0.05),the recurrence rate of cerebral vascular events were lower(P<0.05),the IMT value, patch area and the number of carotid plaques were lower(P<0.05).Conclusion Rosuvastatin and dual antiplatelet combination therapy has good clinical effect for cerebral infarction patients,and have the clinical guiding significance.%目的 探讨瑞舒伐他汀与双抗血小板联合治疗对脑梗死患者血清C反应蛋白(C-reactionprotein,CRP)、脑血管事件复发率及颈动脉斑块的影响.方法 收集铜仁市人民医院神经内科收治的脑梗死患者60例,根据治疗方案不同分为对照组和实验组,每组30例.分别给予相应的药物治疗,治疗结束后,对所有患者的血清CRP水平、颈动脉内膜中膜厚度(intima media thickness, IMT)、斑块面积和斑块数量进行检测,并统计6个月后脑血管事件复发的例数.结果 治疗后,与对照组比较,实验组患者血清CRP水平明显较低(P<0.05);脑血管事件复发率较低(P<0.05);颈动脉斑块的IMT值、斑块面积及斑块数量均明显低于对照组(P<0.05).结论 瑞舒伐他汀与双抗血小板联合治疗脑梗死患者疗效较佳,对临床有指导意义.