多环芳烃类化合物及芳香烃受体在肿瘤发生发展中的作用

摘要

多环芳烃（ polycyclic aromatic hydrocarbons， PAHs）是广泛存在于环境中的污染物，其具有致癌作用已是不争的事实。PAHs能与芳香烃受体（ aryl hydrocarbon receptor， AhR）结合，产生某些毒性反应而发挥致癌作用。 AhR是一种配体依赖性激活转录因子，被PAHs等配体激活后，调控一系列与代谢有关的基因的表达，参与诸如信号转导、细胞增殖与分化、细胞凋亡等重要的生物学过程，且与肿瘤的发生发展密切相关。因此探讨PAHs与AhR在肿瘤发生发展中的作用，可能为肿瘤的预防和治疗提供新途径。%Polycyclic aromatic hydrocarbons ( PAHs) are ubiquitous environmental pollutants, whose carcinogenicity is determinated.The mechanism of their carcinogenicity: PAHs are able to combine with aryl hydrocarbon hydrocarbon receptor ( AhR ) , resulting in some toxicity and carcinogenicity.AhR is a ligand-dependent activation transcription factor, which is activated by a large variety of ligands, regulating the expression of a series of gene involved in metabolism, and participating in important biological processes, such as singal transduction, cell proliferation,differentiation and apoptosis,and so on.Besides, it's closely related with the tumor development.Thus, it will provide a new approach for cancer prevention and treatment to study the role of PAHs and AhR in the development of tumor.