Objective To investigate the changes of VCAM-1 and ICAM-1 levels in tumor and peripheral blood in pancreatic cancer patients. Methods 28 cases with pancreatic cancer were selected from August 2013 to Octorber 2014 as experiment group,28 cases with acute pancreatitis who needed removal of pancreas as control group,28 healthy people as normal group.ICAM-1 and VCAM-1 in tissue were compared and sVCAM-1 and sICAM-1 in serum were compared.Results ICAM-1 and VCAM-1 in tissue of experiment group were significantly higher than normal group(P<0.05), sICAM-1,sVCAM-1 in serum of experiment group were higher than control group and normal group(P<0.05),there were no correlation between CEA and sICAM-1,sVCAM-1 in serum of experiment group(r=0.116,P>0.05;r=0.093,P>0.05),there were positive correlation between CA19-9 and sICAM-1,sVCAM-1 in serum of experiment group(r=0.573,P<0.01;r=0.435,P<0.05).Compared with pre-operation, the serum concentrations of sVCAM-1 and sICAM-1 were lower(P<0.05).Conclusion ICAM-1 and VCAM-1in pancreatic cancer patients are significantly higher than that in acute pancreatitis patients and healthy people, the correlation of ICAM-1 and VCAM-1 expression in pancreatic cancer, early diagnosis and treatment of pancreatic cancer has important significance.%目的：探讨胰腺癌患者瘤体及外周血细胞间粘附分子-l（ intercellular adhesion molecular-l，ICAM-l）和血管细胞间粘附分子-l（ vaseular cell adhesion molecular-l，VCAM-l）水平的变化。方法选取本院2013年8月～2014年10月确诊为胰腺癌的患者28例为实验组，急性胰腺炎需切除胰腺组织28例为对照组，选取28例体检健康者为正常组，测定各组胰腺组织中ICAM-1、VCAM-1水平；检测血清中可溶性细胞间粘附分子（soluble intercellular adhesion molecule-1，sICAM-1）、可溶性血管细胞粘附分子（soluble vascular cell adhesion molecule-1，sVCAM-1）水平。结果实验组组织中ICAM-1、VCAM-1水平显著高于对照组（P＜0.05）；实验组血清中sICAM-1、sVCAM-1浓度水平显著高于对照组和正常组（ P＜0.05）；实验组血清 sICAM-1、sVCAM-1水平与癌胚抗原（ carcino-embryonic antigen，CEA）水平无相关关系（r＝0.116，P＞0.05；r＝0.093，P＞0.05），与CA19-9水平呈正相关（r＝0.573，P＜0.01；r＝0.435，P＜0.05）；实验组手术后血清中sICAM-1、sVCAM-1浓度水平显著低于手术前（P＜0.05）。结论胰腺癌患者瘤体及血清中ICAM-1和VCAM-1显著高于急性胰腺炎患者及正常健康人，ICAM-1和VCAM-1的表达可能与胰腺癌的发生有相关性，对胰腺癌的早期诊疗具有重要的意义。
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