双歧杆菌三联活菌散对感染性腹泻患者肠道菌群和炎症因子的影响

摘要

Objective To study effect of triple viable bacterium of bacillus (small peifeikang) on the intestinal microflora and inflammation factors in patients with infectious diarrhea.Methods From October 2010 to October 2014, 120 patients with infectious diarrhea were chosen as study objects, 30 cases of health examination were selected as healthy control group, All patients were divided into 2 groups:60 patients in small peifeikang group and 60 patients in control group.The therapeutic effect and the change of intestinal microflora and inflammation factors were compared between two groups.Results The effective rate of small peifeikang groupwas 100.00%, while that of control group was 96.67%,the difference had statistical significance (χ2 =5.52,P<0.05).The symptom disappearance time of diarrhea, vomiting and fever had statistical difference between two groups (P<0.05), that of dehydration had no statistical significance.After treatment, in small peifeikang group and control group, the number of bifidobacterium, lactobacillus, and B/E value had decreased significantly (P<0.05), and the number of intestinal bacteriahad increased significantly(P<0.05).The distribution of intestinal flora in small peifeikang group was better than that of control group, and the difference had statistical significance(P<0.05).After treatment, in small peifeikang group and control group, the level of endotoxin, IL -6, TNF-αand CRP had decreased significantly( P <0.05).The extent of decreasing in small peifeikang group was more significant than that of control group, and the difference had statistical significance ( P <0.05 ) . Conclusion The triple viable bacterium of bacillus can promote the recurrence of patients with infectious diarrhea by adjusting the distribution of intestinal microflora, and by its immune regulation function.%目的：研究双歧杆菌三联活菌散（小培菲康）对感染性腹泻患者肠道菌群和炎症因子的影响。方法选取2010年10月～2014年10月期间收治120例急性腹泻患者作为研究对象，选取同一时期来进行健康查体的30例作为健康对照组，将患者分为2组：其中小培菲康组60例（小培菲康1 g／次，3次／d），对照组60例（常规治疗）。比较患者治疗的临床疗效和治疗前后肠道菌群和血清炎症因子的变化。结果小培菲康组治疗有效率100.00％，对照组有效率96.67％，2组患者的临床疗效比较，差异有统计学意义（χ2＝5.52，P＜0.05）。2组患者的腹泻、呕吐和发热消失时间比较，差异有统计学意义（P＜0.05），2组患者脱水症状的消失时间差异无统计学意义。与健康对照组相比，治疗前小培菲康组和对照组患者的双歧杆菌、乳杆菌、B／E值较低，肠杆菌计数较高（P＜0.05）；治疗后，小培菲康组和对照组患者的双歧杆菌、乳杆菌、B／E值均较治疗前显著上升，肠杆菌计数显著下降（P＜0.05），小培菲康组患者肠杆菌、B／E改善较对照组显著（P＜0.05）。治疗前小培菲康组和对照组患者的内毒素、IL-6、TNF-α和CRP水平显著高于健康对照组相比，差异有统计学意义（P＜0.05）；治疗后，2组患者治疗后的内毒素、IL-6、TNF-α和CRP水平显著下降（P＜0.05），其中小培菲康组下降程度较对照组显著（ P＜0.05）。结论双歧杆菌三联活菌散可以通过调整肠道菌群和免疫调节作用而发挥作用，促进感染性腹泻患者的恢复。