Objective To study the expression level clinical significance ofserum AFP (AFP), alpha L- fucus glycosidase (AFU), carcinoembryonic antigen (CEA) and cancer antigen (CA125) in different liver disease and to analyze the diagnostic value to primary liver cancer. Methods From June 2014 to May 2017 in our hospital confirmed by clinical laboratory examination, 120 cases with hepatitis (hepatitis group), 76 cases with cirrhosis (cirrhosis group), 80 cases with primary hepatocellular carcinoma (HCC group) and 72 healthy subjects (control group) at the same period were selected as the research object. Individual serum AFP, AFU, CEA, CA125 and joint detection were performed on 4 groups of subjects, and the results were analyzed. Results Compared with the control group, AFP, AFU, CEA and CA125 were all increased in the hepatitis group, the cirrhosis group and the HCC group AFP (P<0.05). AFP in the HCC group was higher than that in the hepatitis group and was lower than that in the cirrhosis group(P<0.05). The levels of AFU, CEA and CA125 in HCC group were higher than those in hepatitis and cirrhosis group(P<0.05). A single index examination showed that the sensitivity of the AFP was 65.0%. The highest degree of specificity AFU was 69.40%. The positive predictive value was the highest in AFU, 83.33%. The negative predictive value was the highest in AFP, 86.0%; The combined test results showed that the sensitivity and specificity were higher than those in the single test, with a sensitivity of 82.5% and a specificity of 73.13%. Both positive and negative predictors were also higher than those in single tests. Conclusion AFP, AFU, CEA and CA125 in liver disease has important clinical significance, the joint detection can distinguish between the diagnosis of liver cancer and other liver diseases, can improve the sensitivity and accuracy of the diagnosis of liver cancer.%目的 研究不同肝病患者血清甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、癌胚抗原(CEA)及癌抗原(CA125)表达水平和临床意义以及对原发性肝癌的诊断价值分析.方法 选取2014年6月~2017年5月在浙江中医药大学附属第三医院检验科检查确诊的120例肝炎患者(肝炎组)、76例肝硬化患者(肝硬化组)、80例原发性肝癌患者(肝癌组)及同期体检的72名健康者(对照组)作为研究对象.分别对4组研究对象进行单项血清AFP、AFU、CEA、CA125检测和联合检测,然后对结果进行分析.结果 与对照组比较,肝炎组、肝硬化组、肝癌组AFP、AFU、CEA及CA125水平均增加(P<0.05);肝癌组AFP水平高于肝炎组,低于肝硬化组(P<0.05);肝癌组AFU、CEA及CA125水平均高于肝炎组、肝硬化组(P<0.05).单项指标检查表明,灵敏度AFP最高,为65.0%;特异度AFU最高,为69.40%;阳性预测值AFU最高,为83.33%;阴性预测值AFP最高,为86.0%;联合检测结果表明,在灵敏度和特异度上均比单项检测高,其中灵敏度82.5%,特异度73.13%;同样阳性和阴性预测值也均比单项检测高.结论 AFP、AFU、CEA及CA125在肝脏疾病有重要临床意义,联合检测能区分肝癌和其它肝脏疾病的诊断,能提高肝癌诊断的灵敏度和精确度.
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