Objective To explore effect of celecoxib combined with eperisone hydrochloride on the treatment of the quinquagenarian with hyperextension injury of cervical spine. Methods From March 2016 to March 2017, 76 patients with hyperextension injury of cervical spine were treated in the second hospital affiliated to Wenzhou medical university. The patients were selected and randomly divided into two groups according to the random number table. The group A patients were underwent an internal fixation through anterior decompression and combined with celecoxib, eperisone hydrochloride, the group B were underwent anterior decompression and internal fixation only. The improvement of VAS score and ASIA neurological function score were observed preoperative and postoperative period at 4 and 24 weeks between the 2 groups. Results There was no significant difference in ASIA motor and sensory score between the two groups before treatment. The ASIA sensory score in group A was significantly higher than that in group B at 4 weeks and 24 weeks after operation (P<0.05). The VAS score in group A was significantly lower than that in group B at 4 weeks and 24 weeks after operation (P<0.05). Conclusion The combination of celecoxib, eperisone hydrochloride and internal fixation through anterior cervical decompression can improve the neurological function and alleviate the pain of the patients effectively, its clinical efficacy is remarkable.%目的 研究分析塞来昔布、盐酸乙哌立松联合手术治疗颈椎过伸伤的临床疗效.方法 选取2016年3月~2017年3月温州医科大学附属第二医院收治的颈椎过伸伤患者76例,治疗医师按照数字表法将患者随机平分为2组,A组行颈前路减压内固定术联合塞来昔布、盐酸乙哌立松治疗,B组行单纯颈前路减压内固定治疗.观察2组患者术前、术后4周、24周的VAS评分、ASIA神经功能评分改善情况.结果 2组患者治疗前ASIA运动、感觉评分差异无统计学意义;A组后术后4周、24周的ASIA感觉评分显著高于B组,差异具有统计学意义(P<0.05);A组后术后4周、24周的VAS评分显著低于B组(P<0.05).结论 塞来昔布、盐酸乙哌立松联合颈前路减压内固定术治疗颈椎过伸伤,可以有效改善患者神经功能及降低疼痛感,临床疗效显著.
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