SSRI和SNRI药物联合临床护理路径对未治抑郁症患者执行功能影响的对照研究

摘要

目的 观察SSRI和SNRI药物联合临床护理路径对未治抑郁症患者执行功能的影响效果.方法 将2014年10月~2016年4月入住余姚市第三人民医院符合诊断及纳入标准的未治抑郁患者80例,随机分为4组,按照临床给药及护理方式分别定义为SSRIⅠ组、SSRIⅡ组和SNRIⅠ组、SNRIⅡ组,SSRI组均给予患者帕罗西汀8周期口服治疗,Ⅰ组治疗期间则均给予临床常规护理,SNRI组则给予文拉法辛8周期口服治疗,Ⅱ组治疗期间则在常规护理基础上给予临床护理路径干预,评价患者治疗及护理前后执行功能的变化.结果 SSRIⅡ、SNRIⅡ组WCST得分均优于SSRIⅠ、SNRIⅠ组;SNRIⅡ组WCST得分均优于SSRIⅡ组;SSRIⅡ组、SNRIⅡ组TMT评价结果优于SSRIⅠ组、SNRIⅠ组;SNRIⅡ组TMT评价结果优于SSRIⅡ组;SSRIⅡ、SNRIⅡ组TOL实验结果优于SSRIⅠ组、SNRIⅠ组;SNRIⅡ组TOL实验结果优于SSRIⅡ组.结论 SSRI和SNRI药物治疗未治抑郁症患者临床疗效确切,联合临床护理路径干预可有效提高患者执行功能的恢复程度,值得临床应用推广.%Objective To observe the effect of SSRI and SNRI drugs combined with clinical nursing path of untreated depression in patients with executive function. Methods From October 2014 to April 2016, the third people's Hospital of Yuyao was admitted to the 4 people's Hospital, who met the criteria of diagnosis and inclusion criteria. 80 cases of untreated depressive patients were randomly divided into two groups, according to clinical medication and nursing methods were defined as SSRI group, SSRI group and SNRI group, SNRI group, SSRI group were treated with 8 cycles of Pa Rossi Dean oral treatment, during the treatment group were given routine clinical care, SNRI group were given venlafaxine 8 During the period of oral treatment, treatment group Ⅱ were given clinical nursing path on the basis of conventional nursing, treatment and nursing care of patients before and after the change of executive function evaluation. Results SSRI Ⅱ, SNRI Ⅱ group WCST scores were better than SSRI Ⅰ, SNRI Ⅰ group; SNRI group Ⅱ WCST scores were better than SSRI group; SSRI group, SNRI group Ⅱ TMT evaluation results is better than that of SSRI group, SNRI group; SNRI group Ⅱ TMT evaluation results is better than that of SSRI group; the SSRI Ⅱ SNRI Ⅱ group the experimental results of TOL is better than that of SSRI group, SNRI group; SNRI group Ⅱ TOL experimental results better than SSRI Ⅱ group. Conclusion SSRI and SNRI drug treatment untreated depression patients exactly, combined with clinical nursing path can effectively improve the patients with degree of functional recovery, is worthy of clinical application.