Objective To investigate the clinical effect of preoperative XELOX chemotherapy combined with psychological intervention on patients with advanced gastric cancer.Methods The control group, advanced gastric cancer patients underwent surgical treatment, XELOX chemotherapy was given before the operation.The study group was treated with psychological intervention on the basis of the treatment of the control group.The clinical efficacy and adverse reactions of two patients with advanced gastric cancer were recorded.Results Study group five years survival rate(63.83%),disease-free survival(42.55%),no advanced end point event probability(46.81%)was significantly higher than the control group(five and 44.68%year survival rate, disease-free survival rate was 23.40%,no advanced end point event probability 27.66%),data comparison study group P<0.05;wound healing reaction indigestion, gastrointestinal reaction, infection, oral mucositis incidence was significantly lower than the control group(P<0.05).Conclusion In the preoperative XELOX chemotherapy combined with surgical treatment on the basis of advanced gastric cancer with the corresponding psychological intervention can effectively improve the curative effect and prognosis,has positive significance to guarantee the quality of life of patients, life safety.%目的 探讨进展期胃癌患者术前应用XELOX方案化疗联合心理干预的临床效果.方法 对照组进展期胃癌患者接受外科手术治疗,术前给予XELOX方案化疗;研究组在对照组治疗基础上加用相应心理干预措施.记录2组进展期胃癌患者临床疗效、不良反应发生情况.结果 研究组五年生存率(63.83%)、无瘤生存率(42.55%)、无进展期终点事件几率(46.81%)均显著高于对照组(五年生存率44.68%、无瘤生存率23.40%、无进展期终点事件几率27.66%),差异有统计学意义(P＜0.05);研究组切口愈合不良、胃肠道反应、感染、口腔黏膜炎等不良反应发生率显著低于对照组(P＜0.05).结论 在术前XELOX方案化疗联合外科手术治疗基础上,对进展期胃癌患者加用相应心理干预可有效提高其远期疗效、预后,对保障患者生活质量、生命安全均具有积极意义.
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