银杏酮酯滴丸治疗ACS患者PCI术后的临床疗效及对PAR、ACT和ATⅢ的影响

摘要

目的 探讨银杏酮酯滴丸用于急性冠状动脉综合征(ACS)患者经皮冠状动脉介入术(PCI)后的临床疗效及对血小板聚集率(PAR)、活化凝血时间(ACT)和抗凝血酶(AT)Ⅲ的影响.方法 选择2014年1月~2016年10月浙江绿城心血管病医院行PCI的90例ACS患者,通过随机数字表法分为观察组和对照组,每组各45例.对照组在PCI术后给予常规治疗,观察组联用银杏酮酯滴丸.治疗7d后,比较PAR、ACT、ATⅢ的变化及心血管不良事件发生率;治疗3个月后,比较西雅图心绞痛量表结果.结果 治疗后,观察组PAR水平明显低于对照组,ACT、ATⅢ水平明显高于对照组,差异有均统计学意义(P<0.05);观察组心血管不良事件发生率总发生率明显低于对照组,差异有统计学意义(P<0.05);在西雅图心绞痛量表中,观察组心绞痛稳定状态、心绞痛发作情况、躯体活动受限、治疗满意度得分均明显优于对照组,差异有统计学意义(P<0.05).结论 在ACS患者PCI术后应用银杏酮酯滴丸效果显著,可有效缓解临床症状,改善PAR、ACT、ATⅢ表达,有助于降低心血管不良事件发生率.%Objective To investigate curative efficacy of ginkgo biloba extract dripping pills in treatment of acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI) and its effects on platelet aggregation rate(PAR), activated clotting time(ACT) and antithrombin(AT)Ⅲ. Methods 90 patients of ACS treated with PCI who received therapy from January 2014 to October 2016 in Zhejiang green town cardiovascular hospital were selected and randomly divided into the observation group and the control group , 45 cases in each group.The control group was treated with routine treatment after PCI, while the observation group was combined with ginkgo biloba extract dripping pills.After treatment of seven days, the changed of PAR, ACT, ATⅢ and adverse cardiovascular events were compared, after treatment three months, the seattle angina scale were compared. Results After treatment, the levels of PAR in the observation group were significantly lower than that of the control group, and the levels of ACT and ATⅢ were significantly higher than that of the control group, the difference was statistically significant (P<0.05), the total incidence of adverse cardiovascular events in the observation group was significantly lower than that of the control group , the difference was statistically significant ( P<0.05), in the seattle angina scale, the scores of stable state of angina pectoris, the attack of angina pectoris, physical activity limitation, treatment satisfaction in the observation group were significantly better than that of the control group, the difference was statistically significant (P<0.05). Conclusion Ginkgo biloba extract dripping pill is well for ACS after PCI, which can effectively relieve clinical symptoms, to improve the expression of PAR, ACT and ATⅢ, helps to reduce the incidence of adverse cardiovascular events.