复方嗜酸乳杆菌对腹泻型肠易激综合症患者血清SP、VIP、5-HT、IL-6、TNF-α的影响

摘要

Objective To investigate the effect of compound Lactobacillus acidophilus on the levels of serum SP , VIP, 5-HT, IL-6 and TNF-αin patients with diarrhea-predominant irritable bowel syndrome ( IBS) .Methods 82 cases of patients with diarrhea -predominant irritable bowel syndrome ( IBS) from November 2015 to November 2016 in our hospital were selected,and randomly divided into two groups.30 patients in observation group were treated with compound Lactobacillus acidophilus tablets and 52 patients in control group were treated with trimebutine maleate capsule.The levels of serum SP, VIP, 5-HT, IL-6 and TNF-α,quality of life score,clinical curative effect and adverse reaction were observed and compared before and after treatment.Results After treatment,the diarrhea, abdominal distention, defecation frequency and abnormal rate of stool were significantly lower than those before treatment(P <0.05), the levels of SP,VIP,5-HT,IL-6 and TNF-αin serum were significantly lower than those before treatment(P <0.05),and the treatment group were lower than those of the control group.After treatment, the mental status, emotional control and work status scores of the observation group were higher than those of the control group,and the effective rate of the observation group 86.7%was significantly higher than the control group 61.5%,the differences between the two groups were statistically significant (P <0.05).There was no significant adverse events were observed during the treatment.Conclusion Compound Lactobacillus acidophilus is effective in the treatment of diarrhea-predominant irritable bowel syndrome.It can restore the levels of serum SP, VIP, 5-HT, IL-6 and TNF-αin patients with diarrhea-predominant irritable bowel syndrome and improve the quality of life .%目的 探讨复方嗜酸乳杆菌对腹泻型肠易激综合症患者血清SP、VIP、5-HT、IL-6、TNF-α的影响.方法 选取2015年11月~2016年11月台州市立医院收治的82例腹泻型肠易激综合症患者,随机分为2组,观察组30例患者口服复方嗜酸乳杆菌片,对照组52例患者口服马来酸曲美布汀胶囊,观察并比较2组治疗前后的症状,血清SP、VIP、5-HT、IL-6及TNF-α水平,生活质量评分,临床疗效及不良反应情况.结果 治疗后,2组腹泻、腹痛腹胀、排便次数及大便性状异常率明显低于治疗前,且观察组低于对照组,2组治疗后症状比较差异具有统计学意义(P<0.05);治疗后2组患者血清SP、VIP、5-HT、IL-6及TNF-α水平明显低于治疗前,且观察组低于对照组,2组激素水平比较差异显著(P<0.05);观察组治疗后的精神状态、情绪控制及工作状态评分均高于对照组,观察组的有效率86.7%高于对照组61.5%,2组比较差异具有统计学意义(P<0.05).2组治疗期间均未发生明显不良反应.结论 复方嗜酸乳杆菌治疗腹泻型肠易激综合症临床疗效显著,可恢复患者血清SP、VIP、5-HT、IL-6、TNF-α激素水平,提高患者的生活质量和治疗效果.