复方丹参注射液联合玻璃酸钠关节腔内给药对骨性膝关节炎患者炎症反应及膝关节功能的影响

摘要

目的 探讨玻璃酸钠联合复方丹参注射液对骨性膝关节炎患者炎性因子及膝关节功能的影响.方法 选取2015年6月~2016年8月中国人民解放军第404医院收治的骨性关节炎患者78例,随机数表法分成3组,玻璃酸钠治疗组、复方丹参注射液治疗组和玻璃酸钠加复方丹参注射液联合治疗组,每组26例.ELISA检测3组患者治疗前后血清中炎性因子(IL-6、TNF-α及IL-1β)的含量变化,对比分析3种用药方法治疗前后膝关节功能改善情况及疼痛评分变化情况.结果 玻璃酸钠和复方丹参注射液联合用药组总有效率显著高于玻璃酸钠和复方丹参注射液单独用药组(P<0.05);与治疗前相比,治疗后3组患者VAS疼痛评分显著降低,且联合用药组治疗后患者VAS疼痛评分显著低于玻璃酸钠和复方丹参注射液单独用药组(P<0.05);与治疗前相比,治疗后3组IL-6、TNF-α和IL-1β的水平均显著降低(P<0.05),联合用药组的炎性因子水平均显著低于单独用药组(P<0.05).结论 玻璃酸钠和复方丹参注射液联合用药具有良好的协同作用,其能显著降低骨性膝关节炎患者血清中炎性因子水平,减轻患者疼痛并改善患者膝关节功能.%Objective To investigate the clinical curative effect and the influence on knee joint function of knee osteoarthritis treating with sodium hyaluronate combined with compound salvia injection.Methods 78 patients with osteoarthritis treated in our hospital from June 2015 to August 2016 were randomly divided into three groups: sodium hyaluronate group, compound salvia injection group and sodium hyaluronate plus compound salvia injection combination therapy group, 26 cases each group.The levels of serum inflammatory cytokines (IL-6,TNF-αand IL-1β) were measured by ELISA before and after treatment in the three groups, and the improvement of knee joint function and the change of pain score before and after treatment were analyzed as well.Results The total effective rate of sodium hyaluronate combined with compound salvia injection was significantly higher than that of sodium hyaluronate and compound salvia injection alone ( P <0.05 ); after treatment, patients VAS pain score was significantly decreased ( P <0.05), and the VAS pain scores in the combination group were significantly lower than those of the group treated with sodium hyaluronate and the compound salvia injection (P<0.05).The levels of IL-6, TNF-αand IL-1βin the three groups were significantly lower than those before treatment (P<0.05),and the inflammatory factors in the combination group were significantly lower than those in the alone treatment group (P <0.05). Conclusion Sodium hyaluronate combined with compound salvia injection has good clinical curative effect on knee osteoarthritis,improving the function of knee joint, reducing pain and so on.