预测临床孤立综合征转化为多发性硬化相关指标的研究进展

摘要

A clinically isolated syndrome(CIS) is a term that describes a first clinical episode in which a patient has symptoms and signs suggestive of an inflammatory demyelinating disorder of the central nervous system.And it often affects optic nerves,the brainstem,or the spinal cord,and 30％-70％ of the CIS patients may develop multiple sclerosis(MS).Disease-modifying treatments may delay the development from CIS to MS.Their use in CIS is limited because of uncertain long-term clinical prognosis,treatment benefits and adverse effects.This article reviews the advances of predictive markers of conversion to MS after a CIS,in order to provide the reference for clinical treatment.%临床孤立综合征(CIS)是指首次发作的中枢神经系统炎性脱髓鞘事件,病变常累及视神经、脑干或脊髓等部位,30％～ 70％的CIS可转化为多发性硬化(MS).目前认为,疾病修正治疗可延缓CIS向MS的转化,然而因其对疾病最终影响的不确定性及治疗的不良反应,临床使用比较局限且指征严格.现对CIS进展为MS的预测因素的研究进展进行综述,以期为临床治疗提供参考.