The objective of this study was to study the protein interaction network of cattle based on the phylogenetic profile and to provide useful information for the post-genome program of cattle, and the results could be used in production of cattle. The known protein-protein interaction (PPI) data set of C. Eiegans, S. Cerevisiae and Homo sapien were used to deduce the PPI of cattle based on phylogenetic profile in this paper. A PPI network of cattle which included 2 953 proteins and 3 034 interactions was obtained. The analysis of PPI network showed that it was a scale-free property network and 23 unknown proteins including ENSBTAP00000011562 were annotated. The results showed that the partial network related to proteins of lipid metabolism was analyzed based on the known protein information. The result provide effective information for improving the quality and production of milk.%旨在对牛蛋白质相互作用网络进行研究,除了为牛的后基因组学提供研究基础外,其研究成果还可运用到牛的生产实践中.本研究通过系统发育谱法,利用线虫、酵母和人的蛋白相互作用数据对牛的蛋白相互作用进行预测.结果,得到了一个包含2 953个蛋白、3 034对相互作用关系的牛蛋白相互作用网络.分析表明该网络具有scale-free属性,同时对预测出的ENSBTAP00000011562等23个未知功能蛋白进行了诠释.通过结合已有的生物学知识和蛋白的已知功能信息对脂代谢相关蛋白的局部网络进行分析,进一步认识了脂代谢相关机理,为改进牛奶质量和提高牛奶产量提供了有效信息.
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