猪繁殖与呼吸综合征病毒结构和非结构蛋白生物学功能研究进展

摘要

猪繁殖与呼吸综合征严重危害着养猪业的健康发展,给养猪业造成了巨大的经济损失.由于猪繁殖与呼吸综合征病毒(PRRSV)介导的特殊的免疫逃避机制以及抗原性基因的异质性等特征,目前疫苗产品不能提供十分有效的保护.作者就PRRSV结构和非结构蛋白生物学功能的最新研究进展进行归纳总结,以期为PRSSV防控,新型疫苗设计等提供参考.%Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be a threat, and causes huge economic losses in the swine industry. Commercial vaccines are still ineffective as they suffer from both PRRSV-induced immune evasion strategies and the antigenic heterogeneity of the virus. In this paper, the latest research progress of structural and nonstructural proteins of PRRSV are summarized, such as biological functions, which seems to be effective in PRSSV prevention and control, design of new vaccines