瘦素及其受体对肌肉组织蛋白质代谢的调节

摘要

Recent in vivo and in vitro studies showed that the protein metabolism of skeletal muscle and muscular cells could be regulated by long- and short-term treatment of leptin, which was derived from leptin regulating the intracellular signaling pathway, such as the insulin-induced pathway and MAPK pathway. The present paper reviews the rules and mechanisms of leptin and leptin receptor regulating protein metabolism of muscle and muscular cells.%近年来,体内外试验研究表明,瘦素的短期或长期处理能够调节哺乳动物骨骼肌和肌细胞内蛋白质的代谢,而这主要是由于瘦素可以调节肌细胞内与蛋白质代谢相关的信号通路(如胰岛素相关信号通路和丝裂原活化蛋白激酶信号通路)的活性.因此,本文综述了瘦素及其受体在动物体内肌肉组织蛋白质代谢过程中的调节作用,并分析讨论了这一过程中瘦素的可能作用机制,为营养物质通过激素调节蛋白质代谢的深入研究及其应用提供参考.