胰岛素对促性腺激素释放激素分泌及活性的调控

摘要

Insulin is a key hormone in regulating energy metabolism, whereas gonadotropin-releasing hormone (GnRH) is a key hormone in regulating animal reproduction, and an onset factor of empathema of animals. The shorten of time before empathema is important in livestock breeding. It has been widely reported that GnRH can be regulated by insulin in vivo, which controls empathema of animals. This paper mainly reviews the three factors (early growth response protein 1, extracellular regulated kinase and neuropeptide Y) associated with the regulation of insulin on the activity and function of GnRH and summarizes the regulation mechanism of insulin on GnRH in animal breeding.%胰岛素是动物体内能量代谢调控的重要激素,促性腺激素释放激素(GnRH)是动物体内调控繁殖的重要激素,是使动物发情的起始因素.促进家畜尽早进入发情期是现今畜牧业中的一个重要课题.大量研究报道了通过控制动物体内胰岛素水平可影响GnRH水平,从而调控动物发情.本文综述了胰岛素调节GnRH活性和功能过程中早期生长应答蛋白-1、胞外信号调节激酶和神经肽Y发挥的作用,对养殖生产实践中通过胰岛素调控实现GnRH分泌释放的机理作简要的总结.