玉米赤霉烯酮和脱氧血腐镰刀菌烯醇对雌性动物的生殖毒性及作用机制

摘要

镰刀菌毒素玉米赤霉烯酮( ZEA)和脱氧血腐镰刀菌烯醇( DON)广泛存在于受污染的谷物和饲料中。体内和体外研究表明,ZEA和DON均可影响雌性动物的繁殖性能,引起生殖器官、胎儿形态,生殖细胞成熟率,性激素分泌的改变。本文综述了ZEA和DON对雌性动物繁殖性能的影响及潜在的作用机制。%Fusarium mycotoxins, which included zearalenone and deoxynivalenol, are widespread in cereals and feedstuffs. Previous studies showed that ZEA and DON could result in reproductive disorders of female do-mestic animals in vivo and in vitro, such as the functional and morphological alterations in both reproductive or-gans and germ-cell, and the disorder of sex hormones secretion. This paper summarizes individual and com-bined reproductive toxicities of DON and ZEA in female domestic animals. Also, the related mechanisms of the two mycotoxins were discussed.