Sertoli cells play essential roles in the process of spermatogenesis such as maintaining the integrity of blood-testis barrier(BTB),engulfing sperm resid ual cytoplasm and secreting critical cytokines.PA1 has been reported to be a unique component of histone lysine methylation modification complex MLL3/4,regulating gene transcription by histone 3 lysine 4 methylation(H3K4me).However,it is unknown whether PA1 is involved in the epigenetic regulation in male reproductive system.
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