目的：探讨国产和进口两个不同厂家流感病毒裂解疫苗的安全性。方法：通过电话随访和开放式问卷统计2013年9月-2014年1月在中山大学附属第五医院计免门诊接种流感疫苗的568例对象，除去不接受随访的对象，选出391例作为调查对象，追踪观察接种流感疫苗后一周内出现不良反应的症状与体征。将391例研究对象分为6~35个月组和≥3岁组，通过SPSS 19.0软件进行统计学分析，讨论两种疫苗不良反应的差异。结果：葛兰素与华兰生物的流感疫苗总体不良反应发生率分别为4.2%和9.9%，差异有统计学意义(字2=5.016，P<0.05)。6~35个月进口与国产不良反应发生率分别为3.9%和11.8%，差异有统计学意义(字2=6.029，P<0.05)，其中局部反应的发生率为0.6%和4.6%，差异有统计学意义(字2=4.439，P<0.05)。然而≥3岁组进口与国产不良反应发生率分别为4.7%和4.8%，差异无统计学意义(字2<0.001，P>0.05)。结论：6~35个月儿童葛兰素史克的流感疫苗较华兰生物的安全性高。%Objective:To explore the safety about domestic and imported Influenza Split Vaccine from two different manufacturers. Method:Statistics via telephone and open questionnaire showed that there had been 568 cases taking Influenza Vaccine in The Fifth Affiliated Hospital, Sun Yat-sen University from Sep 2013 to Jan 2014.Excluding those people who were not willing to accept the follow-up survey,391 cases were observed on symptoms and signs of adverse reactions within one week after taking influenza vaccine.They were divided into two groups.One was 6-35 months-old group,the other was≥3 years-old group.Then we did statistical analysis with SPSS 19.0 software,and discussed the significance of differences between the adverse reactions caused by these two kinds of vaccine.Result:The Influenza Vaccine adverse reaction rates of Glaxo and Hualan Biological were 4.2%and 9.9%,there were statistically significant(χ²=5.016,P<0.05).The adverse reaction rates of imported and domestic Influenza Vaccine among the 6-35 months-old group were 3.9%and 11.8%,there were statistically significant(χ²=6.029,P<0.05),the local adverse reaction rate were 0.6%and 4.6%, there were statistically significant(χ²=4.439,P<0.05).However,≥3 years-old group,the adverse reaction rates of imported and domestic Influenza Vaccine were 4.7%and 4.8%,there were no statistically significant(χ²<0.001,P>0.05).Conclusion:The Influenza Vaccine from Glaxo Smith Kline is safer than the one from Hualan Biological for 6-35 months-old people.
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