Ruthenium(Ⅱ)-catalyzed para-selective C—H difluoroalkylation of aromatic aldehydes and ketones using transient directing groups

摘要

A Ru(Ⅱ)-catalyzed para-difluoroalkylation of aro matic alde hydes and ketones with a tra nsient directing group has been developed.It utilizes less expensive ruthenium catalysts and allows facile access to challenging difluoroalkylated aldehydes.The mechanism studies suggest that the distinct coordination mode of ruthenium complex with imine moieties is responsible for para-selectivity.