Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C—H activation: Facile synthesis of benzog indolines

摘要

We herein report a highly regioselective rhodium-catalyzed C6-and C7—H bond functionalization of indolines with alkynes by using 2-pyrimidine as a directing group. Moreover, NH-free benzo[g]indole unit could be obtained by an oxidation/removal of the directing group sequence.