Laboratory of Clinical Pharmacology, Cancer Institute, Shanghai Medical University;
Department of Medical Oncology, Cancer Hospital, Shanghai Medical University;
Laboratory of Clinical Pharmacology, Cancer Institute, Shanghai Medical Universityhe effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be im-munomodulators and enhance the antitumor activity of some chemotherapeutic agents.;
alone; antitumor; mitomycin; organs; herbal; sarcoma; preliminary; chemotherapy; Radix; toxicity;
