骨骼肌不仅是机体最重要的运动器官，也是能量代谢的重要场所，其代谢稳态是维持骨骼肌健康乃至整个机体健康的基本前提与重要保证。运动可驯化骨骼肌的能量代谢体系，使其进行积极性调整，并产生显型代谢适应（能量驯化），从而产出更多能量。细胞分子信号调控理论的逐渐丰富与完善，以及线粒体角色的重新转换与定位，为研究骨骼肌能量代谢的运动适应机制提供了崭新视角。作为对能量状态极其敏感的感受器或调节器，AM PK、mTOR、PGC‐1α、p53、SIRT1、FoxOs等关键信号分子及其介导的信号网络的稳态表达对于稳定骨骼肌能量代谢平衡具有不可或缺的重要作用。探寻更多关键信号分子，深入剖析其在物质能量代谢及其与线粒体功能网络之间的信号耦联作用，将会进一步揭示骨骼肌能量代谢稳态的运动适应机制。%Skeletal muscle is not only a most significant motive organ ,but also an important place for energy metabolism .Its metabolic homeostasis is a basic precondition and important guarantee to maintain muscle's health and even the w hole body's health .Exercise can domesti‐cate the energy metabolism system of muscle ,and make sure that it can experience positive ad‐justment and phenotypic adaptation (energy domestication ) as well as produce more energy . The enrichment of molecular and cellular signal pathway theory ,as well as the relocation and conversion of mitochondria offer us a new perspective for exercise‐induced adaptation of muscle energy metabolism .As the most sensitive receptors or regulators of energy state ,key signal molecules such as AMPK ,mTOR ,PGC‐1α ,p53 ,SIRT1 ,FoxOs as well as their signal net‐work are very crucial to maintain muscle energy metabolism .exploring more key signal mole‐cules and analyzing their signal coupling mechanism relevant to energy metabolism and mito‐chondrial function network will further disclose exercise‐induced adaptation of muscle energy metabolism homeostasis mechanism .
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