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中国科学基金：英文版

中国科学基金：英文版

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中国科学基金：英文版 >2020年第2期

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  • 摘要：In February 2018,two research articles were respectively published in Nature Neuroscience (2018,21(4):530—40)and Cell Discovery (2018,4(1):9)to decipher the origins of repopulated microglia in the brain and retina.These two studies,supported by the National Natural Science Foundation of China,were led by Dr.Peng Bo(彭勃)at Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences.
  • 摘要：Most current commercially important hydrocolloids could be considered as dietary fibers.A great deal of research has focused on the bio-function of hydrocolloid materials resulting from their chemical structure,including antioxidant properties,bacteriostatic capacity and cancer prevention.However,the colloidal properties of hydrocolloids in water-holding,high viscosity,gelling and indigestion,which are characterized by macromolecules,also contribute to the human health.Therefore,the nutritional value of hydrocolloids deriving from their colloid properties is defined as colloid nutriology.More specifically,hydrocolloids in this study refer to dietary fibers which are metabolically inert or fermented in the colon or large intestine.Based on this conception,this mini-review attempts to elaborate the nutritional value of hydrocolloids resulting from its colloidal properties.
  • 摘要：With the support by the National Natural Science Foundation of China and National Science and Technology Support Project,the research team led by Prof.Liu Depei(刘德培)at the State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,discovered critical roles of sirtuin 1(SIRT1)in the vascular smooth
  • 摘要：With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Peng Huisheng’s laboratory at the Department of Macromolecular Science,Fudan University,reported a color-tunable,weavable fiber-shaped polymer light-emitting electrochemical cell,which was published in Nature Photonics(2015,9(4):233—238).
  • 摘要：Subject Code:E02 With the support by the National Natural Science Foundation of China,a research team led by Prof.Yu Shuhong(俞书宏)from the University of Science and Technology of China made a breakthrough in the cleanup of viscous crude-oil spill.Their team for the first time realized the fast absorption of high
  • 摘要：With the support of the National Natural Science Foundation of China,the research team directed by Prof.Luo Jun (罗俊)at the MOE Key Laboratory of Fundamental Physical Quantities Measurements & Hubei Key Laboratory of Gravitation and Quantum Physics,School of Physics,Huazhong University of Science and Technology,has measured G with record precision up to date by using two independent methods.The relevant research results were published in Nature (2018,560:582-588).
  • 摘要：Subject Code:F01With the support by the National Natural Science Foundation of China,the research team led by Prof.Peng Lianmao(彭练矛)and Prof.Zhang Zhiyong(张志勇)at the Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics,Peking University,Beijing,recently reported that carbon nanotube CMOS FETs were scaled down to the 5nm gate length and presented
  • 摘要：Supported by the National Science Fund for Distinguished Young Scholars,a team of scientists led by Prof.Chen Hualan in the Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences found that the H5N1 influenza viruses will be transmissible among mammals if they derive certain genes from the widely circulating human H1N1 influenza viruses,and their paper entitled'H5N1
  • 摘要：With the support by the National Natural Science Foundation of China,the research team led by Prof.Fu CaiYun(付彩云)at the College of Life Sciences and Medicine,Zhejiang Sci-Tech University,uncovered antitumor effects and novel molecular mechanisms of neurokinin receptor 1(NK-1R)antagonists,a class of antiemetic drugs used in conjunction with cancer chemotherapy to treat myeloid leukemia,which was published in PNAS(2019,116(39):19635—45).
  • 摘要：Subject Code:D02 With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Wu Xiujie(吴秀杰)from the Institute of Vertebrate Paleontology and Paleoanthropology,Chinese Academy of Sciences and Prof.Erik Trinkaus from Washington
  • 摘要：Due to China's increasing concerns on resource depletion and environmental pollution,traditional linear development approach has to be changed.Circular economy,an approach that proposes a closed-loop of material flows in the economy,is one feasible option since it can add value to businesses and communities by optimizing the use of energy,materials and community resources.Therefore,circular economy has been adopted as a national development strategy since early 2000.Although in existence to some level,the Chinese circular economy policy was recently reinforced through stronger regulatory actions in 2009.That is,an official circular economy promotion law was introduced,emphasizing the circular economy direction of environmental and resource policy for all of China.This emphasis meant that significant additional governmental resources would be invested in this law.It is now just becoming a concern that the law has
  • 摘要：Lipid homeostasis is referred to as the maintenance of stable levels of plasma and cellular lipids and is the result of coordinated regulation of various lipid metabolic pathways.Disruption of lipid homeostasis often results in the development of metabolic disorders including obesity,diabetes and fatty liver formation.With the support from NSFC,Dr.Li Peng's laboratory from Tsinghua University has discovered that CIDE proteins(Cidea,Cideb and Fsp27)are important regulators of lipid homeostasis and has delineated novel molecular pathways in controlling the development of metabolic disorders.
  • 摘要：With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Li Zhou(李舟)at Beijing Nanoenergy and Nanosystems,Chinese Academy of Sciences(CAS),in cooperation with the research team of Prof.Wei Wei from the State Key laboratory of Biochemical Engineering Institute of Process Engineering.
  • 摘要：Prof.Feng Dong’s laboratory at the South China Sea Institute of Oceanology,CAS,reported time integrated variation of sources of fluids and seepage dynamics archived in authigenic carbonate from cold seeps.The results were published in Chemical Geology(2014,385:129—139).A careful examination of the authigenic carbonates from the Gulf of Mexico Gas Hydrate Seafloor Ob-
  • 摘要：With the support of National Natural Science Foundation of China,BGI,the largest genomics organization in the world,and Peking University Shenzhen Hospital,published online in Nature Geneticsics that the study on frequent mutations of chromatin remodeling genes in transitional cell carcinoma(TCC) of the bladder on August 8th,2011.Their study provides a valuable genetic basis for future studies on TCC, suggesting that aberration of chromatin regulation might be one of the features of bladder cancer. According to the article in Nature Geneticstics,bladder cancer is the ninth most common type of cancer worldwide,which affects three times as many men as women.Almost all bladder cancers originate
  • 摘要：When Willis[1]put together his collections of research works about China in 1907,he dedicated a chapter to the geological development of the Yangtze River.He surely did not anticipate that the following century had witnessed great endeavour from a broad scientific community,but with vigorous debates as to when the modern Yangtze came into existence,with estimates ranging from 40—45 Ma,to a more recent initiation around 1 Ma.In year 1914,Ding Wenjiang,a pioneer geologist of China,made a courageous expedition to the upper Yangtze River.Looking down the slope where a tributary joins the Yangtze,he noticed that the north-flowing tributary was too small to make such a wide valley.He further proposed
  • 摘要：An internationally collaborative research team between Prof.Liang YongYe(梁永晔)from the Southern University of Science&Technology and Prof.Wang HaiLiang(王海梁)from Yale University converted carbon emissions to methanol(CH3OH)efficiently by molecular electrocatalysts,which was published in Nature(2019,575(7784):639—642).
  • 摘要：The aim of this study is to discover the molecular mechanism of the 22-week gestated human fetal liver (HFL) which rarely displays both hematopoietic and hepatic functions.Based on large-scale cDNA library sequencing and bioinformatic analysis,the largest gene expression profile of human fetal liver in the world was successfully established.A set of gene clusters func- tionally related to the liver development,hepatocarci- nogenesis and hematopoiesis have been identified.This is for the first time that we could panoramically under- stand the molecular mechanism of the dual functions of human fetal liver.Moreover,201 unrecorded human homologous genes and 609 novel genes have been iden- tified and annotated,which accounting for more than 7% of the known human genes in 2001.In the recent human genome annotation map (human genome build 35. 1 ), 45 genes were nominated based on this study. In addition, we have characterized a set of gene fami- lies represented by hepatopoietin (HPO), Semaphorin, LSECtin and ARFGAP.Two distinctive novel pathways, 'extracellular HPO→HPOreceptor→EGF receptor→Raf→MEK→MAPK' for autocrine and 'intracellular HPO→JAB1→c-JUN(AP-1)' for intracrine of HPO, an unusual cytokine functioned in the regeneration of liver, has been reported for the first time, which have shed new lights on the study of the signal transduction of the entire HPO family.We have also demonstrated that HPO could act as a FAD thioloxidase and that only its intracrine pathway is dependent on the enzymatic activi- ty. It is also known for the first time that the enzyme activity is critically important for the cytokine HPO.Re- garding the regulation of the gene expression of HPO,it was demonstrated that HPO promoter includes a nega- tive regulatory element and a core promoter (comprises an initiator and its flanking three tandem IFE elements). Furthermore,two novel members of Semaphorin family, SEMA6C and SEMA6D,were cloned and shown to be able to determine the orientation of the cell growth.We have also discovered and characterized a novel lectin family including LSECtin, CD23,DC-SIGN and DC- SIGNR.The function of LSECtin was also defined to be important in adhesion of the cells.In addition,the first human member of ARFGAP family was cloned and shown to regulate protein secretion.The publications based on this study have been cited for 145 times by SCl journals before 2005.This study has provided im- portant original data for the annotation of human genome and establishment of human transcriptome.It also played an important role in Chinese national achievement of cloning and annotation of the 10% human cDNAs pro- ject and set up the corner-stone for the leading role of China in the international 'Human Liver Proteome Pro- ject'.
  • 摘要：The 13th Meeting of Heads of Research Councils in Asia(A-HORCs)was held in Okinawa,Japan on November 10,2015.Prof.Gao Wen,Vice President of the National Natural Science Foundation of China(NSFC),Prof.Yuichiro Anzai,President of Japan Society for the Promotion of Science(JSPS)and Prof.Min Keun Chung,President of the National Research Foundation of Korea(NRF)headed their respective delegations to attend the Meeting.
  • 摘要：Subject Code:E02With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof.Tang Yongbing(唐永炳)at the Functional Thin Films Research Center,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,developed a novel tin-graphite dual-ion battery based on sodium-ion electrolyte with high energy density,which
  • 摘要：With the support by the National Natural Science Foundation of China,Prof.Hua Chunsheng and his research mates(Prof.Han Jianda and Associate Prof.Song Dalei)in the State Key Lab of Robotics,Shenyang Institute of Automation,Chinese Academy of Sciences,have reported a long-range pedestrian detection method with monocular camera for the advanced driver assistance system(ADAS),which was pub-
  • 摘要：With the support by the National Natural Science Foundation of China,the research team led by Prof.Yin Zhen (尹振)at Tianjin Polytechnic University,collaborated with the research teams led by Prof.Ma Ding at Peking University and Prof.Wang GuoXiong at Dalian Institute of Chemical Physics,Chinese Academy of Sciences,developed a facile procedure to construct three-dimensional metal-free porous carbon foam with an interface of sp3/sp2 carbon via the pyrolysis of ionic liquids,which exhibited superior catalytic activity towards the oxygen reduction reaction(ORR)under the alkaline medium.This work was published in Ange-w Chem Int Ed(2019,58:15089—15097)and selected as the Hot Paper.
  • 摘要：Prof.Wang Xiangke’s Team at the Plasma Application Division,ACSIPP,in collaboration with Prof.Xu Jinzhang from HeFei University of Technology（HFUT）,developed fluorescent g-C3N4（F-g-C3 N4）,a new type of polymer nanodot that can detect Fe3+and Cu2+ions,via hydrothermal treatment of bulk g-C3N4.This result was published in Nanoscale（2014,6:4157—4162）.
  • 摘要：With the support of the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Qiu Zilong’s group at the Institute of Neuroscience,Chinese Academy of Sciences,unraveled a novel function of autism-related protein MeCP2in the article"MeCP2suppressed nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex"in Developmental Cell(2014,28:547—560).
  • 摘要：In 2011,the Central Government will continue to make a remarkable increase funding for the National Natural Science Fund.The planned amount of funding reaches 12 billion RMB with an increase of over 16%of that of the last year. At the 4th Plenary Session of the 6th NSFC General Assembly held on March 23rd,NSFC President Chen Yiyu said that the Central Government would increase the funding of NSFC in 2011 and the total amount of NSFC funding will reach 12 billion RMB.At the same time,some adjustments will be made to NSFC funding portfolio,e.g.there will be an extension of funding duration and an increase of
  • 摘要：With the support of the National Natural Science Foundation of China,a research team including a group led by Professor Zhang XiuHui(张秀辉)from Beijing Institute of Technology,a group led by Professors Xiao Cheng Zeng and Joseph S.Francisco from the University of Nebraska-Lincoln,a group led by Professor Ge MaoFa from the Institute of Chemistry,Chinese Academy of Sciences,and collaborators from the University of Helsinki,made a major advancement in the study of new particle formation in highly polluted regions.This team work was published in JACS (2018,140(35):11020-11028).
  • 摘要：Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the Research groups led by Prof.Fu Li(付利)from the Cancer Research Center,Shenzhen University School of Medicine and Prof.Guan Xinyuan(关新元)from the University of Hong Kong reported that an
  • 摘要：Prof.Liu Feng’s laboratory at the Institute of Zoology,Chinese Academy of Sciences,published their research findings in an article"Inhibition of endothelial ERK signalling by Smadl/5 is essential for haematopoietic stem cell emergence"in Nature Communications(2014,5:3431).The earliest hematopoietic stem cells(HSCs)are derived from hemogenic endothelium(HE)via en-

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