基于马尔可夫模型比较丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性

摘要

目的：比较丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性。方法：计算机检索ProQuest、PubMed、Springer、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库，收集关于丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性研究，运用TreeAge Pro 2011.1.0.12.1软件构建马尔可夫（Markov）模型，通过计算成本-效果比（CER）对3种药物的经济性作出评价。结果：共纳入6项研究。苯妥英钠的CER值为29.99，丙戊酸钠的CER值为2664.52，托吡酯的CER值为6657.25，即苯妥英钠<丙戊酸钠＜托吡酯。结论：单从经济学方面考虑，苯妥英钠是治疗癫痫最经济、有效的药物。由于纳入研究数量偏少，该结论有待大样本、高质量的研究进一步验证。%OBJECTIVE:To compare economy among sodium valproate (VPA),topiramate (TPM) and dipheninum (DPH) in the treatment of epilepsy (EP). METHODS:Retrieved from ProQuest,PubMed,Springer,CJFD,VIP,Wanfang database,re-searches about economy among VPA,TPM and DPH in the treatment of EP were collected. TreeAge Pro 2011.1.0.12.1 software was used to establish Markov model,and cost-effectiveness ratios (CER) of them were calculated to evaluate their economy. RE-SULTS:CER of DPH,VPA,TPM were 29.99,2 664.52 and 6 657.25,in ascending order of DPH