溴芬酸钠滴眼液治疗干眼症的临床观察

摘要

OBJECTIVE:To observe the clinical efficacy and safety of Bromfenac sodium eyed drops in the treatment of xe-rophthalmia. METHODS:80 patients with xerophthalmia were randomly divided into observation group and control group,with 40 cases in each group. Control group was given 0.1% Sodium hyaluronate,one drop,qd;observation group was given 0.1% Sodi-um hyaluronate eye drops,one drop,bid. Both groups received 14 d of treatment. The subjective symptom and sign,the time of lacrimal film break-up,fluorescent staining score and schemer test were observed in 2 groups before treatment,3,7,14 d after treatment. Clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS:There was no statistical significance in subjective symptom and sign,the time of lacrimal film break-up,fluorescent staining score and tear between 2 groups before treatment,3,7 d after treatment(P>0.05). 14 d after treatment,subjective symptom and sign and fluorescent staining score of 2 groups were decreased significantly,and the time of lacrimal film break-up was prolonged and secretion was increased significant-ly;the observation group was significantly better than the control group,with statistical significance (P0.05). CONCLUSIONS:Sodium hyaluronate eye drops is effective for xerophthalmia,and can relieve the symptoms with good safety.%目的：观察溴芬酸钠滴眼液治疗干眼症的临床疗效及安全性。方法：将80例干眼症患者按随机数字表法分为对照组和观察组，各40例。对照组患者给予0.1％浓度的玻璃酸钠滴眼液1滴，qd；观察组患者给予0.1％的溴芬酸钠滴眼液1滴，bid。两组患者均治疗14 d。观察两组患者治疗前及治疗后3、7、14 d自觉症状和体征、泪膜破裂时间及荧光素染色评分，采用泪液分泌试验（schimer）测量泪液分泌量，并比较两组患者临床疗效及不良反应发生情况。结果：治疗前及治疗后3、7 d，两组患者自觉症状和体征、泪膜破裂时间、荧光素染色评分及泪液分泌量比较，差异均无统计学意义（P＞0.05）；治疗后14 d，两组患者自觉症状和体征、荧光素染色评分显著降低，泪膜破裂时间显著延长，泪液分泌量明显增加，且观察组明显优于对照组，差异均有统计学意义（P＜0.05）。观察组患者治愈率为60.0％，显著高于对照组的35.0％，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：溴芬酸钠滴眼液治疗干眼症疗效显著，能够有效缓解患者干眼症状，且安全性较好。