盐酸法舒地尔与奥扎格雷钠注射剂体外配伍稳定性考察

摘要

目的:考察盐酸法舒地尔与奥扎格雷钠注射液的配伍稳定性.方法:采用HPLC法测定室温(25℃)条件下配伍溶液放置8 h两药的含量变化,并考察配伍前后外观、性状、pH及不溶性微粒的变化.结果:注射用盐酸法舒地尔与奥扎格雷钠配伍后在室温下放置8 h,配伍溶液的外观、性状、pH及不溶性微粒无明显变化,两药的含量仍在97%以上.结论:盐酸法舒地尔注射液与奥扎格雷钠注射液配伍8 h内未发现明显变化.%Objective: To study the compatibility of fasudil hydrochloride injection and ozagrel sodium injection.Method: The changes in pH value, external appearance and insoluble particles of the two preparations were observed and their relative contents were determined by HPLC within 8 h after the compatibility at room temperature.Result: There were no significant changes in all the tested indices of the two preparations in 8 h after the compatibility.The relative contents were both above 97％ at the end of the experiment.Conclusion: There are no significant changes in fasudil hydrochloride injection and ozagrel sodium injection in 8 hour compatibility.