热原诱导的Toll样受体信号传导通路研究进展

摘要

本文概述了脂多糖、脂磷壁酸和酵母多糖这3种常见热原诱导炎症细胞分泌细胞因子,发生炎症反应的机制.重点介绍了热原的分类以及这三种热原的胞外传递过程和相应Toll样受体介导的胞内信号传导通路.%Lipopolysaccharide(LPS),lipteichoic acid(LTA) and zymosan can be recognized by Toll-like receptors (TLRs) ex-pressing in the inflammatory cells membrane,such as macrophages,monocytes and endothelial cells,and then induce the secretion of pyrogenic cytokines followed by triggering inflammatory reaction. The signaling pathway mechanisms were summarized, including the extracellular signaling cascades from pyrogens to individual TLRs,and intracellular signaling cascades from TLRs to nucleus.