Objective To investigate the influence of two kinds of induction chemotherapy program on the demand of blood products in children with acute lymphoblastic leukemia. Methods To compare and analyze the clinical data of blood products infusion during two kinds of induction chemotherapy program in 38 children cases of primary acute lymphoblastic leukemia. Results The consumption amount of red blood cell suspension in the 06 program group was (2. 875 ± 1. 450) U/(10 kg ? Per person), which was higher than (0.722 ±0. 826)U/(10kg ? Per person) in the 05 program, and the consumption amount of platelets pheresis was (2. 2 ± 1. 735)U/per person and higher than (0. 556 ± 1. 450) U/(10 kg ? Per person) in the 05 program group. The differences were statistically significant. The intravenous gamma globulin, fibrinogen and human serum albumin consumption in the 06 program were also higher than those in the 05 program. The bone marrow remission rates between the two groups were similar (100% vs. 94. 4% ). Conclusion The induction chemotherapy intensity of the 05 program in the children patients with acute lymphoblastic leukemia is lower than that of the 06 program with high bone marrow remission rate and obviously lower demand of the blood products than the 06 program.%目的 探讨两种诱导化疗方案对急性淋巴细胞白血病患儿血制品需求的影响.方法 分析38例初发急性淋巴细胞白血病患儿两种方案诱导化疗期间血制品输注的临床资料.结果 06方案组红细胞悬液的消耗量为(2.875±1.450)U/( 10 kg·人),高于05方案组的(0.722±0.826)U/(10 kg·人),单采血小板的消耗量为(2.2±1.735)U/人,高于05方案组的(0.556±1.199)U/人,差异有统计学意义(P＜0.05).06方案组在静脉丙种球蛋白、纤维蛋白原和人血白蛋白的消耗上也多于05方案组.骨髓缓解率二者相近(100％vs94.4％).结论 急性淋巴细胞白血病患儿05方案组诱导化疗强度低于06方案组,其骨髓缓解率高,而其血制品的需要量明显少于06方案组.
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