转铁蛋白-转铁蛋白受体在肿瘤主动靶向治疗中的应用

摘要

Transferrin - transferrin receptor mediated drug delivery system can improve the uptake of drugs in tumor cells, reduce toxicity and improve initiative targeted activities. This review has summed up the characteristics of transferrin and transferrin receptor, the classification of transferrin - transferrin receptor mediated nano - drug delivery system and transferrin - transferrin receptor in targeted tumor treatment. In addition, the current defects and prospects is indicated.%转铁蛋白-转铁蛋白受体介导的给药系统可以提高肿瘤细胞对药物的摄取量,降低药物毒性,提高药物的主动靶向性.该文综述了转铁蛋白和转铁蛋白受体的特点,转铁蛋白-转铁蛋白受体介导的纳米给药系统的分类,转铁蛋白-转铁蛋白受体在肿瘤疾病靶向治疗中的应用,并指出了当前转铁蛋白-转铁蛋白受体及其介导的纳米给药系统在肿瘤治疗上的不足与发展前景.