十一酸睾酮对骨质疏松老年男性骨量及骨代谢的影响

摘要

目的：观察十一酸睾酮对骨质疏松老年男性患者骨量及骨代谢的影响。方法选择2013年1月至2014年12月收治的骨质疏松症患者100例，随机分为对照组和观察组，各50例。两组均给予钙剂、维生素D、降钙素等促进骨化抑制骨吸收的药物治疗，观察组加用十一酸睾酮。两组患者均以4周为1个疗程，治疗3个疗程。结果观察组总有效率为98.00%，高于对照组的86.00%（ P﹤0.05）。治疗前，两组患者腰椎正位、股骨颈的骨密度（BMD）、各项骨代谢指标无明显差异（ P﹥0.05）；治疗后，两组患者BMD、各项骨代谢指标均显著改善，且观察组改善情况显著优于对照组（ P﹤0.05）。两组患者不良反应均较轻，差异无统计学意义（ P﹥0.05）。结论十一酸睾酮对骨质疏松老年男性患者具有治疗作用，临床疗效显著，减轻疼痛，可影响患者骨量及骨代谢，且无明显不良反应发生，值得临床推广。%Objective To observe the influence of testosterone undecanoate on bone mass and bone metabolism in elderly male patients with osteoporosis. Methods 100 cases of osteoporosis patients admitted to the hospital from January 2013 to December 2014 were ran-domly divided into the control group and the observation group, 50 cases in each group. The two groups were treated with calcium, vita-min D, calcitonin to promote ossification and inhibit bone absorption, and the observation group was added with testosterone unde-canoate. 4 weeks was 1 course of treatment and the two groups were treated for 3 courses. Results The total effective rate of the ob-servation group was 98. 00%, which was higher than 86. 00% in the control group ( P ﹤ 0. 05 ) . The lumbar spine and femoral neck BMD of the two groups had no significant difference before treatment, after treatment( P ﹥ 0. 05), the BMD of the two groups signifi-cantly improved, and the improvement of the observation group was significantly better than that of the control group. The bone metabolism of the two groups had no significant difference before treatment. After treatment, the bone metabolism of the two groups were significantly improved, and the improvement of the observation group was significantly better than that of the control group. The adverse reactions in the two groups were mild, and the difference between the incidence rate of the two groups was not statistically significant ( P ﹥ 0. 05 ) . Conclusion Testosterone undecanoate has a therapeutic effect in treating elderly male patients with osteoporosis; it has significant clinical effect, can affect bone mass and bone metabolism, reduce pain, with no significant adverse reactions, and thus is worth of clinical promotion.