Objective To investigate the clinical effect of recombinant human interferon alpha-2b gel in treating chronic cervicitis compli-cating high-risk HPV infections. Methods 76 patients with chronic cervicitis complicating vaginal high-risk HPV infection in the gynecolo-gy and obstetrics department of our hospital from April 2010 to March 2014 were selected and divided into the study group and the con-trol group according to the random number table method,38 cases in each group. The control group was given chlorquinaldol promestriene vaginal tablets,while on this basis the study group was added with recombinant human interferon alpha-2b gel by placing in the deep vagina. Results The cervical erosion degree in 3 months after treatment had no statistically significant difference between the two groups;the cervical erosion degree in 6,12 months after treatment in the study group was lighter than that in the control group( P < 0. 05). The HPV negative conversion rates at 3,6,12 months after treatment in the study group intervention were higher than those in the control group( P < 0. 05). The total effective rate in the study group was 94. 74%,which was significantly higher than 81. 58% in the control group( P < 0. 05). No obvious adverse reactions appeared during treatment process. Conclusion Recombinant human iinterferon alpha-2b gel combined with chlorquinaldol promestriene vaginal tablets in treating chronic cervicitis complicating vaginal high-risk HPV infection can effectively control the cervical inflammation,improve the HPV negative conversion rate,have high safety,which is worthy of promotion.%目的：探讨重组人干扰素α－2b凝胶治疗慢性宫颈炎并发阴道高危型人乳头状瘤病毒（HPV）感染患者的临床疗效。方法选取医院妇产科2010年4月至2014年3月收治的76例确诊患者，采用随机数字表法分为研究组和对照组，各38例。对照组给予氯喹那多－普罗雌烯阴道片，研究组加用重组人干扰素α－2b凝胶治疗，均阴道深处放置。结果两组患者治疗3个月时宫颈糜烂程度差异无统计学意义；治疗后第6，12个月时研究组宫颈糜烂程度轻于对照组（ P＜0.05），研究组治疗后第3，6，12个月的HPV转阴率均高于对照组（ P＜0.05）；研究组治疗总有效率为94.74%，明显高于对照组的81.58%（ P＜0.05）。两组患者治疗期间均未出现明显不良反应。结论重组人干扰素α－2b凝胶联合氯喹那多－普罗雌烯阴道片治疗慢性宫颈炎合并阴道高危型HPV感染者，能有效控制宫颈炎症，提高HPV转阴率，安全性高，值得推广。
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