目的 探讨CT引导精准微波消融联合奥沙利铂肝动脉灌注化学治疗(简称化疗)栓塞术(TACE)对原发性肝癌(PHC)患者生存率及免疫功能的影响.方法 选择医院2013年1月至12月收治的原发性肝癌患者102例,采用随机数字表法分为对照组和观察组,各51例.对照组患者给予奥沙利铂TACE治疗,观察组患者采用奥沙利铂TACE联合CT引导精准微波消融治疗.治疗3个月后检测免疫功能相关指标;两组患者均获得随访,以2016年12月31日或死亡为随访终点,比较两组患者1,2,3年生存情况.结果 治疗3个月后,两组患者补体C3及C4,免疫球蛋白IgA,IgG,IgM水平均较治疗前明显升高(P0.05).结论 CT引导精准微波消融联合奥沙利铂TACE治疗原发性肝癌可增强患者免疫功能,提高生存率,且不增加并发症发生率,值得临床推广.%Objective To investigate the influence of CT guided precision microwave ablation combined with Oxaliplatin into transcatheter arterial chemoembolization(TACE) on the survival rate and immune function of patients with primary hepatocellular carcinoma(PHC). Methods Totally 102 patients with PHC from January to December 2013 admitted to the hospital were randomly divided into two groups, 51 cases in each group. The control group was given Oxaliplatin into TACE,on this basis,the observation group was added CT guided pre-cision microwave ablation. After 3 months treatment,the related parameters of immune function were tested. All patients were followed up,the end of follow-up was followed by December 31,2016 or death. 1,2,3 year survival rates of the two groups were compared. Results Three months after treatment,the levels of C3,C4,IgA,IgG,IgM in the two groups were significantly higher than before treatment (P 0. 05). Conclusion CT guided precision microwave ablation combined with Oxaliplatin into TACE can enhance the immune function in patients with PHC,improve the survival rate,and does not increase the risk of complications,it is worthy of clinical promotion.
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